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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VCL

Summary for VCL

Gene information	Gene symbol	VCL
	Ensembl ID	ENSG00000035403
	Entrez ID	7414
	Gene name	vinculin
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VCL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.658363	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.320536	4.62e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.51058	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.618689	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.491344	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.261229	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.643338	0.00e+00

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Expression of VCL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VCL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VCL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VCL	hsa-miR-21-5p	98.5774	NM_003373
VCL	hsa-miR-590-5p	98.0772	NM_003373
VCL	hsa-miR-589-3p	95.6005	NM_003373
VCL	hsa-miR-4303	95.2018	NM_003373
VCL	hsa-miR-5196-5p	94.4183	NM_014000
VCL	hsa-miR-4747-5p	94.4183	NM_014000
VCL	hsa-miR-9-5p	93.905	NM_003373
VCL	hsa-miR-1827	93.2581	NM_014000
VCL	hsa-miR-4668-5p	93.002	NM_014000
VCL	hsa-miR-5196-3p	92.6461	NM_014000
VCL	hsa-miR-548an	92.3878	NM_003373
VCL	hsa-miR-6740-3p	92.2885	NM_014000
VCL	hsa-miR-374c-3p	91.6843	NM_003373
VCL	hsa-miR-12119	91.5936	NM_003373
VCL	hsa-miR-1248	91.3939	NM_003373
VCL	hsa-miR-1-5p	91.3902	NM_014000
VCL	hsa-miR-4255	91.3835	NM_003373
VCL	hsa-miR-12128	91.3829	NM_003373
VCL	hsa-miR-6808-5p	90.2465	NM_003373
VCL	hsa-let-7f-1-3p	89.1177	NM_014000
VCL	hsa-let-7a-3p	89.1177	NM_014000
VCL	hsa-let-7b-3p	89.1177	NM_014000
VCL	hsa-miR-98-3p	89.1177	NM_014000
VCL	hsa-miR-6868-3p	88.8656	NM_014000
VCL	hsa-miR-3910	88.8482	NM_003373
VCL	hsa-miR-450a-1-3p	87.9431	NM_014000
VCL	hsa-miR-940	87.8384	NM_003373
VCL	hsa-miR-6893-5p	87.8384	NM_003373
VCL	hsa-let-7f-2-3p	87.0613	NM_014000
VCL	hsa-miR-1185-2-3p	87.0613	NM_014000
VCL	hsa-miR-1185-1-3p	87.0613	NM_014000
VCL	hsa-miR-6736-3p	86.85	NM_003373
VCL	hsa-miR-6739-5p	84.993	NM_014000
VCL	hsa-miR-6733-5p	84.993	NM_014000
VCL	hsa-miR-34c-5p	83.4083	NM_003373
VCL	hsa-miR-449a	83.4083	NM_003373
VCL	hsa-miR-449b-5p	83.4083	NM_003373
VCL	hsa-miR-34a-5p	83.4083	NM_003373
VCL	hsa-miR-6876-5p	82.6138	NM_014000
VCL	hsa-miR-124-5p	82.0889	NM_003373
VCL	hsa-miR-586	82.0067	NM_014000
VCL	hsa-miR-4703-3p	81.5885	NM_014000
VCL	hsa-miR-340-5p	81.4749	NM_003373
VCL	hsa-miR-105-5p	81.2322	NM_014000
VCL	hsa-miR-7853-5p	81.2322	NM_014000
VCL	hsa-miR-3153	80.8777	NM_014000
VCL	hsa-miR-548e-5p	80.7591	NM_014000
VCL	hsa-miR-6511a-5p	80.6286	NM_014000

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Motifs and transcription factors (TFs) regulating VCL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VCL	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
VCL	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
VCL	jaspar__MA1122.1	TFDP1 (directAnnotation).
VCL	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
VCL	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
VCL	jaspar__MA0748.2	YY2 (directAnnotation).
VCL	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
VCL	kznf__ZNF273_Imbeault2017_RP_RCADE	ZNF273 (directAnnotation).
VCL	swissregulon__hs__HBP1	HBP1 (directAnnotation).
VCL	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
VCL	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
VCL	transfac_public__M00051	NFKB1 (directAnnotation).
VCL	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
VCL	metacluster_143.13	ZBTB7A (directAnnotation).
VCL	transfac_pro__M05845	ZSCAN29 (directAnnotation).
VCL	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
VCL	transfac_pro__M06181	ZNF165 (directAnnotation).
VCL	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
VCL	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
VCL	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
VCL	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).
VCL	hdpi__GTF3C2	GTF3C2 (directAnnotation).
VCL	metacluster_198.3	ZFP64 (directAnnotation).
VCL	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
VCL	hdpi__NRL	NRL (directAnnotation).
VCL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
VCL	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
VCL	cisbp__M00968	MTF2 (directAnnotation).
VCL	transfac_pro__M00716	ZBTB14 (directAnnotation).
VCL	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
VCL	transfac_pro__M02089	E2F3 (directAnnotation).
VCL	transfac_pro__M07310	SP5 (directAnnotation).
VCL	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
VCL	hdpi__HIP2	UBE2K (directAnnotation).
VCL	transfac_pro__M07387	ZBTB7A (directAnnotation).
VCL	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
VCL	transfac_pro__M01783	SP2 (directAnnotation).
VCL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
VCL	cisbp__M07938	E2F1 (directAnnotation).
VCL	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
VCL	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
VCL	metacluster_135.11	NR2C2 (directAnnotation).
VCL	cisbp__M00788	ZFY (inferredBy_Orthology).
VCL	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
VCL	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
VCL	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
VCL	cisbp__M00343	PAX6 (directAnnotation).
VCL	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
VCL	transfac_pro__M00938	E2F1 (directAnnotation).
VCL	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."