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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: VAT1

Summary for VAT1

Gene informationGene symbol

VAT1

Ensembl ID

ENSG00000108828

Entrez ID

10493

Gene namevesicle amine transport 1
SynonymsFLJ20230|VATI
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: VAT1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells0.600241.33e-03

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro0.2985349.84e-43

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells0.2609622.51e-39

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells0.3058990.00e+00

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells0.3007999.09e-15

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells0.2566471.41e-05

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.6350740.00e+00

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.284487.97e-08

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Expression of VAT1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to VAT1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VAT1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
VAT1hsa-miR-6825-5p99.8974NM_006373
VAT1hsa-miR-63698.3154NM_006373
VAT1hsa-miR-182798.0834NM_006373
VAT1hsa-miR-218-5p98.0688NM_006373
VAT1hsa-miR-6763-5p97.7538NM_006373
VAT1hsa-miR-506-3p97.1261NM_006373
VAT1hsa-miR-124-3p97.1261NM_006373
VAT1hsa-miR-3150a-3p96.8859NM_006373
VAT1hsa-miR-371494.5043NM_006373
VAT1hsa-miR-96-5p93.9958NM_006373
VAT1hsa-miR-1271-5p92.9958NM_006373
VAT1hsa-miR-939-5p91.9587NM_006373
VAT1hsa-miR-1343-5p91.9587NM_006373
VAT1hsa-miR-317591.1665NM_006373
VAT1hsa-miR-30a-5p91.105NM_006373
VAT1hsa-miR-30c-5p91.105NM_006373
VAT1hsa-miR-30b-5p91.105NM_006373
VAT1hsa-miR-30d-5p91.105NM_006373
VAT1hsa-miR-30e-5p91.105NM_006373
VAT1hsa-miR-1207-5p90.7807NM_006373
VAT1hsa-miR-1213390.7707NM_006373
VAT1hsa-miR-311988.1297NM_006373
VAT1hsa-miR-4720-3p87.8218NM_006373
VAT1hsa-miR-4708-3p86.3644NM_006373
VAT1hsa-miR-848585.6268NM_006373
VAT1hsa-miR-4763-3p85.2231NM_006373
VAT1hsa-miR-6884-5p84.8897NM_006373
VAT1hsa-miR-485-5p84.8897NM_006373
VAT1hsa-miR-425784.6433NM_006373
VAT1hsa-miR-605-3p84.3512NM_006373
VAT1hsa-miR-808983.6245NM_006373
VAT1hsa-miR-212-5p83.0786NM_006373
VAT1hsa-miR-465182.9333NM_006373
VAT1hsa-miR-60882.9333NM_006373
VAT1hsa-miR-6810-5p82.0316NM_006373
VAT1hsa-miR-7106-5p81.6979NM_006373
VAT1hsa-miR-4728-5p81.0253NM_006373
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Motifs and transcription factors (TFs) regulating VAT1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
VAT1metacluster_55.5ZNF541 (directAnnotation).
VAT1transfac_pro__M04748GABPA (directAnnotation).
VAT1metacluster_22.37BACH1 (directAnnotation).
VAT1transfac_pro__M06117ZNF23 (directAnnotation).
VAT1metacluster_155.30ZNF254 (directAnnotation).
VAT1transfac_pro__M07260IKZF1 (directAnnotation).
VAT1transfac_pro__M01835KLF4 (directAnnotation).
VAT1hocomoco__PATZ1_HUMAN.H11MO.1.CPATZ1 (directAnnotation).
VAT1taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAPETV4; GCM1 (directAnnotation).
VAT1metacluster_172.6CHD2; E2F1 (directAnnotation).
VAT1taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
VAT1transfac_pro__M05612ZNF189 (directAnnotation).
VAT1tfdimers__MD00208IRF1; LTF (directAnnotation).
Page: 1

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."