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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VASP

Summary for VASP

Gene information	Gene symbol	VASP
	Ensembl ID	ENSG00000125753
	Entrez ID	7408
	Gene name	vasodilator stimulated phosphoprotein
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VASP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.283302	1.78e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.314605	1.35e-03
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.286314	3.25e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.381342	5.78e-11
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	-0.305348	5.33e-31
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.374134	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.282995	6.99e-21
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.271221	6.19e-10
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.302222	2.23e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.402981	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.570525	0.00e+00

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Expression of VASP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VASP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VASP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VASP	hsa-miR-5011-5p	99.9416	NM_003370
VASP	hsa-miR-190a-3p	99.3591	NM_003370
VASP	hsa-miR-548aj-3p	96.0146	NM_003370
VASP	hsa-miR-548x-3p	96.0146	NM_003370
VASP	hsa-miR-1323	95.9907	NM_003370
VASP	hsa-miR-548ap-3p	95.3346	NM_003370
VASP	hsa-miR-548aa	95.3346	NM_003370
VASP	hsa-miR-548t-3p	95.3346	NM_003370
VASP	hsa-miR-3059-5p	94.7321	NM_003370
VASP	hsa-miR-670-3p	94.0384	NM_003370
VASP	hsa-miR-548o-3p	93.448	NM_003370
VASP	hsa-miR-1238-3p	93.3705	NM_003370
VASP	hsa-miR-548aq-3p	93.2316	NM_003370
VASP	hsa-miR-548ae-3p	93.2316	NM_003370
VASP	hsa-miR-548ah-3p	93.2316	NM_003370
VASP	hsa-miR-548j-3p	93.2316	NM_003370
VASP	hsa-miR-548am-3p	93.2316	NM_003370
VASP	hsa-miR-2355-5p	92.662	NM_003370
VASP	hsa-miR-3691-3p	91.9838	NM_003370
VASP	hsa-miR-1277-5p	91.3509	NM_003370
VASP	hsa-miR-3609	90.2945	NM_003370
VASP	hsa-miR-548ah-5p	90.2945	NM_003370
VASP	hsa-miR-6881-5p	87.7565	NM_003370
VASP	hsa-miR-4763-3p	87.3089	NM_003370
VASP	hsa-miR-1207-5p	87.3089	NM_003370
VASP	hsa-miR-548e-3p	84.9022	NM_003370
VASP	hsa-miR-548bc	84.9022	NM_003370
VASP	hsa-miR-548f-3p	84.9022	NM_003370
VASP	hsa-miR-548ar-3p	84.9022	NM_003370
VASP	hsa-miR-548a-3p	84.9022	NM_003370
VASP	hsa-miR-548az-3p	84.9022	NM_003370
VASP	hsa-miR-6126	84.7512	NM_003370
VASP	hsa-miR-3910	83.1328	NM_003370
VASP	hsa-miR-4291	82.3708	NM_003370
VASP	hsa-miR-4455	82.3683	NM_003370
VASP	hsa-miR-20a-5p	81.8382	NM_003370
VASP	hsa-miR-106b-5p	81.8382	NM_003370
VASP	hsa-miR-4796-3p	81.8382	NM_003370
VASP	hsa-miR-1913	80.0641	NM_003370

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Motifs and transcription factors (TFs) regulating VASP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VASP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
VASP	transfac_pro__M05628	ZNF735 (directAnnotation).
VASP	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
VASP	transfac_pro__M06404	ZNF497 (directAnnotation).
VASP	transfac_pro__M05411	ZNF784 (inferredBy_Orthology).
VASP	transfac_pro__M05984	ZNF586 (directAnnotation).
VASP	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
VASP	tfdimers__MD00330	FOXP3; HSF1 (directAnnotation).
VASP	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
VASP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
VASP	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
VASP	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
VASP	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
VASP	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
VASP	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
VASP	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
VASP	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
VASP	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
VASP	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
VASP	metacluster_183.4	ETS1 (inferredBy_Orthology).
VASP	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
VASP	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
VASP	transfac_pro__M06347	ZNF782 (directAnnotation).
VASP	metacluster_130.9	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
VASP	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
VASP	transfac_pro__M06331	ZNF343 (directAnnotation).
VASP	metacluster_59.1	HOXA9; HOXA9; HOXA9; HOXB6; HOXB7; HOXB7; HOXB8; HOXB8; HOXC6; HOXC8; HOXC8; MEIS1; MEIS1; MEIS2; MEIS2; PBX1; PBX1; PBX1; PBX2; PBX2 (directAnnotation). HOXA9; HOXA9; HOXB4; HOXB6; HOXC6; HOXC9; HOXC9; LEF1; PDX1; PDX1; TCF7L2 (inferredBy_Orthology).
VASP	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_2	SPIB; TEAD4 (directAnnotation).
VASP	taipale_cyt_meth__PITX2_YTAATCCN_FL	PITX2 (directAnnotation).
VASP	transfac_pro__M02843	BBX (inferredBy_Orthology).
VASP	metacluster_141.2	E2F2; E2F3 (directAnnotation).
VASP	tfdimers__MD00014	ARID3A; KLF4 (directAnnotation).
VASP	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).
VASP	tfdimers__MD00097	GABPA; PAX4 (directAnnotation).
VASP	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."