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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VAMP4

Summary for VAMP4

Gene information	Gene symbol	VAMP4
	Ensembl ID	ENSG00000117533
	Entrez ID	8674
	Gene name	vesicle associated membrane protein 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O75379

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Dataset with differentially expressed gene: VAMP4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.642036	1.42e-05

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Expression of VAMP4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VAMP4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VAMP4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VAMP4	hsa-miR-5011-5p	99.9998	NM_003762
VAMP4	hsa-miR-190a-3p	99.9997	NM_001185127
VAMP4	hsa-miR-4789-5p	99.8468	NM_001185127
VAMP4	hsa-miR-6867-5p	99.2176	NM_003762
VAMP4	hsa-miR-3613-3p	96.9023	NM_001185127
VAMP4	hsa-miR-3688-3p	95.5355	NM_003762
VAMP4	hsa-miR-5696	94.6579	NM_003762
VAMP4	hsa-miR-3163	94.1062	NM_001185127
VAMP4	hsa-miR-607	93.4697	NM_001185127
VAMP4	hsa-miR-3148	93.1932	NM_001185127
VAMP4	hsa-miR-944	93.0003	NM_003762
VAMP4	hsa-miR-7159-3p	92.3472	NM_003762
VAMP4	hsa-miR-544a	92.174	NM_003762
VAMP4	hsa-miR-520d-5p	91.8555	NM_001185127
VAMP4	hsa-miR-524-5p	91.8555	NM_001185127
VAMP4	hsa-miR-4474-3p	91.8356	NM_003762
VAMP4	hsa-miR-153-5p	90.8441	NM_003762
VAMP4	hsa-miR-4282	90.7297	NM_001185127
VAMP4	hsa-miR-4517	89.3947	NM_003762
VAMP4	hsa-miR-1-3p	88.895	NM_001185127
VAMP4	hsa-miR-206	88.895	NM_001185127
VAMP4	hsa-miR-613	88.3722	NM_001185127
VAMP4	hsa-miR-3616-3p	87.1553	NM_001185127
VAMP4	hsa-miR-570-3p	86.747	NM_001185127
VAMP4	hsa-miR-1250-3p	86.5777	NM_003762
VAMP4	hsa-miR-3973	86.3228	NM_003762
VAMP4	hsa-miR-4307	85.8905	NM_003762
VAMP4	hsa-miR-1252-3p	84.9937	NM_003762
VAMP4	hsa-miR-518a-5p	83.7958	NM_001185127
VAMP4	hsa-miR-527	83.7958	NM_001185127
VAMP4	hsa-miR-590-3p	83.6873	NM_003762
VAMP4	hsa-miR-6500-3p	83.5325	NM_003762
VAMP4	hsa-miR-5583-3p	83.4988	NM_003762
VAMP4	hsa-miR-12132	83.299	NM_003762
VAMP4	hsa-miR-6837-3p	82.9195	NM_003762
VAMP4	hsa-miR-3152-5p	82.755	NM_001185127
VAMP4	hsa-miR-10397-5p	82.6949	NM_003762
VAMP4	hsa-miR-6757-3p	82.689	NM_003762
VAMP4	hsa-miR-4446-5p	82.4399	NM_003762
VAMP4	hsa-miR-8062	81.9799	NM_003762
VAMP4	hsa-miR-4719	81.5756	NM_001185127
VAMP4	hsa-miR-548aw	81.2407	NM_001185127
VAMP4	hsa-miR-587	81.2043	NM_003762

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Motifs and transcription factors (TFs) regulating VAMP4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VAMP4	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
VAMP4	transfac_pro__M04617	ZBTB7A (directAnnotation).
VAMP4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
VAMP4	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
VAMP4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
VAMP4	transfac_pro__M07387	ZBTB7A (directAnnotation).
VAMP4	transfac_pro__M07436	WT1 (directAnnotation).
VAMP4	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
VAMP4	transfac_pro__M00716	ZBTB14 (directAnnotation).
VAMP4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
VAMP4	hdpi__HIP2	UBE2K (directAnnotation).
VAMP4	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
VAMP4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
VAMP4	transfac_pro__M04893	TAF1 (directAnnotation).
VAMP4	transfac_pro__M03876	ZBTB33 (directAnnotation).
VAMP4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
VAMP4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
VAMP4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
VAMP4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."