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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VAMP3

Summary for VAMP3

Gene information	Gene symbol	VAMP3
	Ensembl ID	ENSG00000049245
	Entrez ID	9341
	Gene name	vesicle associated membrane protein 3
	Synonyms	CEB
	Gene type	protein_coding
	UniProtAcc	Q15836

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Dataset with differentially expressed gene: VAMP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.444115	5.54e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.317266	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.288762	0.00e+00

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Expression of VAMP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VAMP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VAMP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VAMP3	hsa-miR-182-5p	99.033	NM_004781
VAMP3	hsa-miR-124-3p	98.8156	NM_004781
VAMP3	hsa-miR-506-3p	98.8156	NM_004781
VAMP3	hsa-miR-96-5p	98.2136	NM_004781
VAMP3	hsa-miR-504-3p	97.5554	NM_004781
VAMP3	hsa-miR-1271-5p	97.4262	NM_004781
VAMP3	hsa-miR-12133	97.4262	NM_004781
VAMP3	hsa-miR-1468-3p	96.9629	NM_004781
VAMP3	hsa-miR-100-3p	94.2358	NM_004781
VAMP3	hsa-miR-548an	93.6183	NM_004781
VAMP3	hsa-miR-3202	93.445	NM_004781
VAMP3	hsa-miR-4533	93.445	NM_004781
VAMP3	hsa-miR-7977	93.1907	NM_004781
VAMP3	hsa-miR-6515-3p	92.8269	NM_004781
VAMP3	hsa-miR-6511b-5p	92.449	NM_004781
VAMP3	hsa-miR-6811-5p	92.449	NM_004781
VAMP3	hsa-miR-4640-5p	92.4289	NM_004781
VAMP3	hsa-miR-5197-5p	92.2467	NM_004781
VAMP3	hsa-miR-2115-3p	91.6883	NM_004781
VAMP3	hsa-miR-3920	91.5967	NM_004781
VAMP3	hsa-miR-520f-3p	91.5776	NM_004781
VAMP3	hsa-miR-384	91.5097	NM_004781
VAMP3	hsa-miR-4726-5p	91.2777	NM_004781
VAMP3	hsa-miR-676-5p	91.1406	NM_004781
VAMP3	hsa-miR-103b	89.7997	NM_004781
VAMP3	hsa-miR-3910	89.2816	NM_004781
VAMP3	hsa-miR-196a-1-3p	88.5655	NM_004781
VAMP3	hsa-miR-34b-5p	88.5499	NM_004781
VAMP3	hsa-miR-449c-5p	88.5499	NM_004781
VAMP3	hsa-miR-605-3p	87.5641	NM_004781
VAMP3	hsa-miR-122-5p	87.4872	NM_004781
VAMP3	hsa-miR-1226-3p	87.2864	NM_004781
VAMP3	hsa-miR-19b-3p	86.3789	NM_004781
VAMP3	hsa-miR-19a-3p	86.3789	NM_004781
VAMP3	hsa-miR-142-3p	86.3696	NM_004781
VAMP3	hsa-miR-9-5p	84.8749	NM_004781
VAMP3	hsa-miR-4635	84.8018	NM_004781
VAMP3	hsa-miR-2682-5p	84.5439	NM_004781
VAMP3	hsa-miR-4690-3p	83.8518	NM_004781
VAMP3	hsa-miR-5685	83.8518	NM_004781
VAMP3	hsa-miR-4496	83.2371	NM_004781
VAMP3	hsa-miR-152-5p	82.6034	NM_004781
VAMP3	hsa-miR-199a-3p	81.5337	NM_004781
VAMP3	hsa-miR-199b-3p	81.5337	NM_004781
VAMP3	hsa-miR-3129-5p	81.4876	NM_004781

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Motifs and transcription factors (TFs) regulating VAMP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VAMP3	metacluster_7.13	ZFX (directAnnotation).
VAMP3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
VAMP3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
VAMP3	transfac_pro__M05479	ZNF580 (directAnnotation).
VAMP3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
VAMP3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
VAMP3	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
VAMP3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
VAMP3	jaspar__MA0079.5	SP1 (directAnnotation).
VAMP3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
VAMP3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
VAMP3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
VAMP3	transfac_pro__M01199	TRIM28 (directAnnotation).
VAMP3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
VAMP3	jaspar__MA0748.2	YY2 (directAnnotation).
VAMP3	transfac_pro__M12697	ZNF142 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."