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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UXS1

Summary for UXS1

Gene information	Gene symbol	UXS1
	Ensembl ID	ENSG00000115652
	Entrez ID	80146
	Gene name	UDP-glucuronate decarboxylase 1
	Synonyms	FLJ23591\|SDR6E1\|UGD
	Gene type	protein_coding
	UniProtAcc	Q8NBZ7

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Dataset with differentially expressed gene: UXS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.338666	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.750082	0.00e+00

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Expression of UXS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UXS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UXS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UXS1	hsa-miR-607	94.6557	NM_001253875
UXS1	hsa-miR-4680-3p	93.879	NM_001253876
UXS1	hsa-miR-6513-3p	93.6867	NM_001253875
UXS1	hsa-miR-552-5p	92.4249	NM_001253876
UXS1	hsa-miR-4708-3p	92.4016	NM_001253875
UXS1	hsa-miR-18a-3p	91.3857	NM_001253876
UXS1	hsa-miR-153-3p	91.3466	NM_001253875
UXS1	hsa-miR-5692a	90.8409	NM_001253875
UXS1	hsa-miR-491-3p	90.5184	NM_001253875
UXS1	hsa-miR-451b	90.1787	NM_001253875
UXS1	hsa-miR-1264	89.834	NM_001253875
UXS1	hsa-miR-519a-3p	89.8004	NM_001253875
UXS1	hsa-miR-519b-3p	89.8004	NM_001253875
UXS1	hsa-miR-519c-3p	89.8004	NM_001253875
UXS1	hsa-miR-145-5p	89.6654	NM_001253875
UXS1	hsa-miR-5195-3p	89.6654	NM_001253875
UXS1	hsa-miR-520g-3p	89.0753	NM_001253875
UXS1	hsa-miR-520h	89.0753	NM_001253875
UXS1	hsa-miR-3973	89.0753	NM_001253875
UXS1	hsa-miR-4477a	88.5379	NM_001253875
UXS1	hsa-miR-4423-3p	87.865	NM_001253875
UXS1	hsa-miR-5582-5p	85.5648	NM_001253875
UXS1	hsa-miR-93-5p	85.481	NM_001253875
UXS1	hsa-miR-106b-5p	85.481	NM_001253875
UXS1	hsa-miR-20a-5p	85.481	NM_001253875
UXS1	hsa-miR-17-5p	85.481	NM_001253875
UXS1	hsa-miR-519d-3p	85.481	NM_001253875
UXS1	hsa-miR-106a-5p	85.481	NM_001253875
UXS1	hsa-miR-526b-3p	85.481	NM_001253875
UXS1	hsa-miR-20b-5p	85.481	NM_001253875
UXS1	hsa-miR-8062	84.9459	NM_001253875
UXS1	hsa-miR-6073	84.8151	NM_001253875
UXS1	hsa-miR-9-3p	84.3242	NM_001253876
UXS1	hsa-miR-577	83.8174	NM_001253875
UXS1	hsa-miR-6830-3p	82.8886	NM_001253875
UXS1	hsa-miR-4704-3p	81.8455	NM_001253875
UXS1	hsa-miR-548ar-3p	81.4941	NM_001253876
UXS1	hsa-miR-22-5p	80.6038	NM_001253876

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Motifs and transcription factors (TFs) regulating UXS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UXS1	metacluster_7.13	ZFX (directAnnotation).
UXS1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
UXS1	metacluster_151.2	ZNF23 (directAnnotation).
UXS1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
UXS1	transfac_pro__M05479	ZNF580 (directAnnotation).
UXS1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
UXS1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UXS1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
UXS1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UXS1	jaspar__MA0079.5	SP1 (directAnnotation).
UXS1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
UXS1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
UXS1	transfac_pro__M06331	ZNF343 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."