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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UTY

Summary for UTY

Gene information	Gene symbol	UTY
	Ensembl ID	ENSG00000183878
	Entrez ID	7404
	Gene name	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
	Synonyms	KDM6AL\|KDM6C
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: UTY

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.291613	4.95e-10

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Expression of UTY in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UTY

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UTY

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UTY	hsa-miR-3163	99.4507	NM_001258269
UTY	hsa-miR-4762-5p	99.1042	NM_001258269
UTY	hsa-miR-335-3p	98.0147	NM_001258269
UTY	hsa-miR-3605-5p	96.6788	NM_001258268
UTY	hsa-miR-5582-3p	96.336	NM_001258269
UTY	hsa-miR-151b	95.791	NM_001258269
UTY	hsa-miR-151a-5p	95.791	NM_001258269
UTY	hsa-miR-190a-3p	94.5137	NM_001258269
UTY	hsa-miR-4789-3p	93.7487	NM_001258269
UTY	hsa-miR-520f-5p	93.5546	NM_001258269
UTY	hsa-miR-4328	93.4251	NM_001258269
UTY	hsa-miR-4748	93.3782	NM_001258255
UTY	hsa-miR-4464	93.3782	NM_001258255
UTY	hsa-miR-1284	92.9321	NM_001258255
UTY	hsa-miR-2117	92.6577	NM_001258255
UTY	hsa-miR-4468	92.4629	NM_001258269
UTY	hsa-miR-4742-3p	91.1225	NM_001258269
UTY	hsa-miR-216a-5p	90.9411	NM_001258255
UTY	hsa-miR-3662	90.8486	NM_001258269
UTY	hsa-miR-6798-3p	90.7991	NM_182659
UTY	hsa-miR-4719	90.6566	NM_001258255
UTY	hsa-miR-4709-5p	90.5598	NM_001258269
UTY	hsa-miR-2278	90.3681	NM_001258269
UTY	hsa-miR-466	89.805	NM_001258269
UTY	hsa-miR-656-3p	88.5028	NM_001258269
UTY	hsa-miR-196a-1-3p	88.2622	NM_001258269
UTY	hsa-miR-371a-5p	88.2401	NM_001258269
UTY	hsa-miR-651-3p	87.7991	NM_001258269
UTY	hsa-miR-6838-3p	86.3094	NM_001258269
UTY	hsa-miR-5007-3p	86.3037	NM_001258255
UTY	hsa-miR-153-3p	84.0815	NM_001258269
UTY	hsa-miR-548au-3p	83.4517	NM_001258269
UTY	hsa-miR-208a-5p	83.1338	NM_001258255
UTY	hsa-miR-208b-5p	83.1338	NM_001258255
UTY	hsa-miR-494-3p	82.7553	NM_001258255
UTY	hsa-miR-3646	82.511	NM_001258269
UTY	hsa-miR-5011-5p	82.497	NM_001258269
UTY	hsa-miR-4307	82.3258	NM_001258269
UTY	hsa-miR-4643	81.4193	NM_001258269
UTY	hsa-miR-8485	81.3762	NM_001258255
UTY	hsa-miR-513b-3p	80.4016	NM_182659
UTY	hsa-miR-6844	80.3742	NM_001258255

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Motifs and transcription factors (TFs) regulating UTY

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UTY	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
UTY	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
UTY	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
UTY	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
UTY	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
UTY	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
UTY	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
UTY	jaspar__MA0748.2	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."