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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP6NL

Summary for USP6NL

Gene information	Gene symbol	USP6NL
	Ensembl ID	ENSG00000148429
	Entrez ID	9712
	Gene name	USP6 N-terminal like
	Synonyms	KIAA0019\|RN-tre\|RNTRE\|TRE2NL\|USP6NL-IT1
	Gene type	protein_coding
	UniProtAcc	Q92738

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Dataset with differentially expressed gene: USP6NL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.459901	0.00e+00

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Expression of USP6NL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP6NL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP6NL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP6NL	hsa-miR-5011-5p	100	NM_001080491
USP6NL	hsa-miR-190a-3p	100	NM_001080491
USP6NL	hsa-miR-139-5p	99.1485	NM_001080491
USP6NL	hsa-miR-590-3p	96.0258	NM_014688
USP6NL	hsa-miR-498-3p	95.9509	NM_001080491
USP6NL	hsa-miR-3908	95.8297	NM_001080491
USP6NL	hsa-miR-584-5p	95.8209	NM_014688
USP6NL	hsa-let-7a-2-3p	94.8472	NM_001080491
USP6NL	hsa-let-7g-3p	94.8472	NM_001080491
USP6NL	hsa-miR-767-5p	93.8601	NM_001080491
USP6NL	hsa-miR-6839-5p	93.7696	NM_014688
USP6NL	hsa-miR-4697-3p	93.6431	NM_014688
USP6NL	hsa-miR-378j	92.1244	NM_014688
USP6NL	hsa-miR-448	92.0554	NM_014688
USP6NL	hsa-miR-9983-3p	92.0357	NM_014688
USP6NL	hsa-miR-3680-3p	92.0066	NM_014688
USP6NL	hsa-miR-5690	91.9641	NM_014688
USP6NL	hsa-miR-12122	91.925	NM_001080491
USP6NL	hsa-miR-6882-5p	91.5556	NM_014688
USP6NL	hsa-miR-29c-3p	91.2775	NM_001080491
USP6NL	hsa-miR-29b-3p	91.2775	NM_001080491
USP6NL	hsa-miR-29a-3p	91.2775	NM_001080491
USP6NL	hsa-miR-142-3p	91.0767	NM_001080491
USP6NL	hsa-miR-182-5p	90.2758	NM_014688
USP6NL	hsa-miR-129-5p	89.1438	NM_014688
USP6NL	hsa-miR-577	89.1335	NM_001080491
USP6NL	hsa-miR-200b-3p	87.595	NM_001080491
USP6NL	hsa-miR-429	87.595	NM_001080491
USP6NL	hsa-miR-200c-3p	87.595	NM_001080491
USP6NL	hsa-miR-4503	86.6546	NM_001080491
USP6NL	hsa-miR-4531	86.5659	NM_014688
USP6NL	hsa-miR-26a-1-3p	85.8806	NM_014688
USP6NL	hsa-miR-26a-2-3p	85.8806	NM_014688
USP6NL	hsa-miR-124-5p	85.2551	NM_014688
USP6NL	hsa-miR-548c-3p	84.9254	NM_001080491
USP6NL	hsa-miR-4775	84.6736	NM_014688
USP6NL	hsa-miR-4797-5p	84.2484	NM_014688
USP6NL	hsa-miR-194-5p	84.0002	NM_014688
USP6NL	hsa-miR-548n	83.9843	NM_014688
USP6NL	hsa-miR-4758-3p	83.5164	NM_014688
USP6NL	hsa-miR-3691-5p	83.2939	NM_014688
USP6NL	hsa-miR-6873-3p	83.2211	NM_001080491
USP6NL	hsa-miR-6854-3p	82.4466	NM_014688
USP6NL	hsa-miR-651-3p	81.0204	NM_001080491
USP6NL	hsa-miR-3200-3p	80.4493	NM_001080491
USP6NL	hsa-miR-889-3p	80.3002	NM_014688

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Motifs and transcription factors (TFs) regulating USP6NL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP6NL	metacluster_135.11	NR2C2 (directAnnotation).
USP6NL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP6NL	tfdimers__MD00038	TFAP2C (directAnnotation).
USP6NL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
USP6NL	metacluster_7.13	ZFX (directAnnotation).
USP6NL	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
USP6NL	cisbp__M00968	MTF2 (directAnnotation).
USP6NL	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP6NL	metacluster_160.20	JUND; PRDM15 (directAnnotation).
USP6NL	cisbp__M00341	PAX6 (directAnnotation).
USP6NL	metacluster_198.3	ZFP64 (directAnnotation).
USP6NL	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP6NL	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
USP6NL	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
USP6NL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
USP6NL	cisbp__M00788	ZFY (inferredBy_Orthology).
USP6NL	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
USP6NL	metacluster_175.1	ZNF283 (directAnnotation).
USP6NL	hdpi__ZNF304	ZNF304 (directAnnotation).
USP6NL	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
USP6NL	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
USP6NL	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
USP6NL	transfac_pro__M01199	TRIM28 (directAnnotation).
USP6NL	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
USP6NL	metacluster_151.2	ZNF23 (directAnnotation).
USP6NL	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP6NL	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
USP6NL	transfac_pro__M03806	ZBTB7C (directAnnotation).
USP6NL	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."