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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP47

Summary for USP47

Gene information	Gene symbol	USP47
	Ensembl ID	ENSG00000170242
	Entrez ID	55031
	Gene name	ubiquitin specific peptidase 47
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q96K76

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Dataset with differentially expressed gene: USP47

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.271687	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.720639	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.275118	0.00e+00

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Expression of USP47 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP47

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP47

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP47	hsa-miR-208b-5p	99.4209	NM_001282659
USP47	hsa-miR-208a-5p	99.4209	NM_001282659
USP47	hsa-miR-627-3p	93.8548	NM_001282659
USP47	hsa-miR-101-3p	92.7112	NM_001282659
USP47	hsa-miR-1323	92.5604	NM_001282659
USP47	hsa-miR-548aw	91.9787	NM_001282659
USP47	hsa-miR-4711-5p	90.7081	NM_001282659
USP47	hsa-miR-548o-3p	89.3356	NM_001282659
USP47	hsa-miR-4426	88.8538	NM_001282659
USP47	hsa-miR-3668	88.3565	NM_001282659
USP47	hsa-miR-6853-3p	87.8317	NM_001282659
USP47	hsa-miR-4662b	86.7341	NM_001282659
USP47	hsa-miR-4647	86.7341	NM_001282659
USP47	hsa-miR-1304-5p	86.3692	NM_001282659
USP47	hsa-miR-576-5p	84.8514	NM_001282659
USP47	hsa-miR-450b-5p	84.6262	NM_001282659
USP47	hsa-miR-663b	83.9271	NM_001282659
USP47	hsa-miR-6809-3p	83.7505	NM_001282659
USP47	hsa-miR-4668-3p	83.1565	NM_001282659
USP47	hsa-miR-3646	83.05	NM_001282659
USP47	hsa-miR-4477a	83.0173	NM_001282659
USP47	hsa-miR-6832-3p	82.2403	NM_001282659
USP47	hsa-miR-3975	81.233	NM_001282659

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Motifs and transcription factors (TFs) regulating USP47

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP47	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
USP47	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
USP47	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
USP47	metacluster_3.14	WT1; WT1 (directAnnotation).
USP47	metacluster_135.11	NR2C2 (directAnnotation).
USP47	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP47	tfdimers__MD00038	TFAP2C (directAnnotation).
USP47	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
USP47	metacluster_7.13	ZFX (directAnnotation).
USP47	cisbp__M00968	MTF2 (directAnnotation).
USP47	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP47	metacluster_160.20	JUND; PRDM15 (directAnnotation).
USP47	cisbp__M00341	PAX6 (directAnnotation).
USP47	metacluster_198.3	ZFP64 (directAnnotation).
USP47	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP47	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
USP47	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
USP47	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
USP47	cisbp__M00788	ZFY (inferredBy_Orthology).
USP47	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
USP47	metacluster_175.1	ZNF283 (directAnnotation).
USP47	hdpi__ZNF304	ZNF304 (directAnnotation).
USP47	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
USP47	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
USP47	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
USP47	transfac_pro__M01199	TRIM28 (directAnnotation).
USP47	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
USP47	metacluster_151.2	ZNF23 (directAnnotation).
USP47	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP47	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
USP47	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP47	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
USP47	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
USP47	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."