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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: USP38

Summary for USP38

Gene informationGene symbol

USP38

Ensembl ID

ENSG00000170185

Entrez ID

84640

Gene nameubiquitin specific peptidase 38
SynonymsHP43.8KD|KIAA1891
Gene typeprotein_coding
UniProtAcc

Q8NB14


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Dataset with differentially expressed gene: USP38

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.6433740.00e+00

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Expression of USP38 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to USP38

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP38

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
USP38hsa-miR-153-5p99.7651NM_032557
USP38hsa-miR-548ar-3p96.8593NM_001290326
USP38hsa-miR-808496.7556NM_032557
USP38hsa-miR-590-3p96.5883NM_032557
USP38hsa-miR-548bc96.0884NM_001290326
USP38hsa-miR-548f-3p96.0884NM_001290326
USP38hsa-miR-548a-3p96.0884NM_001290326
USP38hsa-miR-548az-3p96.0884NM_001290326
USP38hsa-miR-548e-3p96.0884NM_001290326
USP38hsa-miR-7113-3p95.6721NM_032557
USP38hsa-miR-212-3p95.6503NM_032557
USP38hsa-miR-132-3p95.6503NM_032557
USP38hsa-miR-345-3p94.1197NM_032557
USP38hsa-miR-33a-3p92.4792NM_032557
USP38hsa-let-7e-5p92.4643NM_032557
USP38hsa-let-7d-5p92.4643NM_032557
USP38hsa-miR-445892.4643NM_032557
USP38hsa-let-7b-5p92.4643NM_032557
USP38hsa-let-7c-5p92.4643NM_032557
USP38hsa-let-7i-5p92.4643NM_032557
USP38hsa-miR-98-5p92.4643NM_032557
USP38hsa-let-7a-5p92.4643NM_032557
USP38hsa-let-7f-5p92.4643NM_032557
USP38hsa-let-7g-5p92.4643NM_032557
USP38hsa-miR-807692.2919NM_001290326
USP38hsa-miR-450091.7347NM_032557
USP38hsa-miR-6509-5p91.554NM_001290326
USP38hsa-miR-500a-5p90.8756NM_001290326
USP38hsa-miR-585-5p90.6317NM_032557
USP38hsa-miR-129089.4315NM_001290326
USP38hsa-miR-429189.3313NM_001290326
USP38hsa-miR-569689.3111NM_001290326
USP38hsa-miR-4662a-3p89.2034NM_001290326
USP38hsa-miR-5196-3p88.967NM_001290325
USP38hsa-miR-340-5p88.952NM_032557
USP38hsa-miR-205388.8952NM_001290326
USP38hsa-miR-1211988.4497NM_001290326
USP38hsa-miR-7856-5p87.6551NM_001290326
USP38hsa-miR-4436b-5p87.272NM_001290326
USP38hsa-miR-1212087.1128NM_001290325
USP38hsa-miR-182587.0015NM_032557
USP38hsa-miR-183-3p86.7526NM_001290326
USP38hsa-miR-431986.3456NM_032557
USP38hsa-miR-5011-5p86.1567NM_001290326
USP38hsa-miR-127285.8929NM_001290326
USP38hsa-miR-445285.6455NM_001290326
USP38hsa-miR-7114-5p85.6442NM_001290326
USP38hsa-miR-376c-5p85.6378NM_001290326
USP38hsa-miR-376b-5p85.6378NM_001290326
USP38hsa-miR-6884-5p85.4261NM_001290325
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Motifs and transcription factors (TFs) regulating USP38

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
USP38metacluster_135.11NR2C2 (directAnnotation).
USP38metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP38tfdimers__MD00038TFAP2C (directAnnotation).
USP38metacluster_144.3ZNF704; ZNF704 (directAnnotation).
USP38metacluster_7.13ZFX (directAnnotation).
USP38cisbp__M00968MTF2 (directAnnotation).
USP38metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP38metacluster_160.20JUND; PRDM15 (directAnnotation).
USP38cisbp__M00341PAX6 (directAnnotation).
USP38metacluster_198.3ZFP64 (directAnnotation).
USP38metacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP38metacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
USP38metacluster_61.1DEAF1; DEAF1 (directAnnotation).
USP38cisbp__M00788ZFY (inferredBy_Orthology).
USP38kznf__ZNF213_Schmitges2016_RCADEZNF213 (directAnnotation).
USP38metacluster_175.1ZNF283 (directAnnotation).
USP38hdpi__ZNF304ZNF304 (directAnnotation).
USP38transfac_pro__M02844BCL6B (inferredBy_Orthology).
USP38metacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
USP38metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
USP38transfac_pro__M01199TRIM28 (directAnnotation).
USP38kznf__ZNF682_Isakova2017_SMiLE-seqZNF682 (directAnnotation).
USP38metacluster_151.2ZNF23 (directAnnotation).
USP38transfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP38transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
USP38transfac_pro__M03806ZBTB7C (directAnnotation).
USP38transfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."