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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP22

Summary for USP22

Gene information	Gene symbol	USP22
	Ensembl ID	ENSG00000124422
	Entrez ID	23326
	Gene name	ubiquitin specific peptidase 22
	Synonyms	KIAA1063\|USP3L
	Gene type	protein_coding
	UniProtAcc	Q9UPT9

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Dataset with differentially expressed gene: USP22

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.727526	8.63e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	1.15956	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.408022	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.333648	1.29e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.288346	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.365605	3.99e-21
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.332644	9.87e-11

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Expression of USP22 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP22

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
USP22	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating USP22

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP22	hsa-miR-6851-5p	90.5328	NM_015276
USP22	hsa-miR-3689d	90.3207	NM_015276
USP22	hsa-miR-153-5p	88.0555	NM_015276
USP22	hsa-miR-3148	87.7617	NM_015276
USP22	hsa-miR-6864-3p	86.2089	NM_015276
USP22	hsa-miR-3672	86.2089	NM_015276
USP22	hsa-miR-6833-5p	84.2518	NM_015276
USP22	hsa-miR-4316	83.7569	NM_015276
USP22	hsa-miR-3202	83.6514	NM_015276
USP22	hsa-miR-1343-5p	83.6388	NM_015276
USP22	hsa-miR-939-5p	83.6388	NM_015276
USP22	hsa-miR-4760-3p	83.3806	NM_015276
USP22	hsa-miR-10393-5p	80.5806	NM_015276

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Motifs and transcription factors (TFs) regulating USP22

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP22	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
USP22	transfac_pro__M07397	ZNF148 (directAnnotation).
USP22	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
USP22	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
USP22	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
USP22	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
USP22	transfac_pro__M01175	ZBTB7B (directAnnotation).
USP22	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
USP22	tfdimers__MD00151	CHURC1 (directAnnotation).
USP22	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
USP22	transfac_pro__M01303	SP1 (directAnnotation).
USP22	swissregulon__hs__CHD1	CHD1 (directAnnotation).
USP22	transfac_pro__M01714	KLF15 (directAnnotation).
USP22	transfac_pro__M02089	E2F3 (directAnnotation).
USP22	metacluster_3.14	WT1; WT1 (directAnnotation).
USP22	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
USP22	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
USP22	transfac_pro__M02898	SMAD3 (directAnnotation).
USP22	transfac_public__M00491	PATZ1 (directAnnotation).
USP22	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
USP22	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
USP22	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
USP22	transfac_pro__M04866	HDAC2 (directAnnotation).
USP22	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
USP22	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
USP22	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
USP22	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
USP22	transfac_pro__M04617	ZBTB7A (directAnnotation).
USP22	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
USP22	transfac_pro__M07387	ZBTB7A (directAnnotation).
USP22	transfac_pro__M07436	WT1 (directAnnotation).
USP22	transfac_pro__M00716	ZBTB14 (directAnnotation).
USP22	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
USP22	transfac_pro__M04893	TAF1 (directAnnotation).
USP22	transfac_pro__M03876	ZBTB33 (directAnnotation).
USP22	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
USP22	metacluster_7.13	ZFX (directAnnotation).
USP22	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
USP22	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
USP22	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
USP22	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP22	cisbp__M01863	ZNF711 (inferredBy_Orthology).
USP22	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
USP22	jaspar__MA0079.5	SP1 (directAnnotation).
USP22	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
USP22	transfac_pro__M04817	ZBTB33 (directAnnotation).
USP22	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
USP22	jaspar__MA1125.1	ZNF384 (directAnnotation).
USP22	transfac_pro__M07270	TEAD4 (directAnnotation).
USP22	metacluster_52.11	ZNF184 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."