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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: USP14

Summary for USP14

Gene information	Gene symbol	USP14
	Ensembl ID	ENSG00000101557
	Entrez ID	9097
	Gene name	ubiquitin specific peptidase 14
	Synonyms	TGT\|Ubp6
	Gene type	protein_coding
	UniProtAcc	P54578

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Dataset with differentially expressed gene: USP14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.498942	7.09e-06
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.251951	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.3437	7.23e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.307067	3.48e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.257	5.40e-10
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.317176	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.389944	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.750527	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.390049	0.00e+00

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Expression of USP14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
USP14	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating USP14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP14	hsa-miR-4795-3p	99.0955	NM_001037334
USP14	hsa-miR-124-3p	98.1386	NM_001037334
USP14	hsa-miR-506-3p	98.1386	NM_001037334
USP14	hsa-miR-6887-3p	97.1994	NM_005151
USP14	hsa-miR-3714	97.111	NM_001037334
USP14	hsa-miR-3910	96.9073	NM_001037334
USP14	hsa-miR-8068	93.2311	NM_005151
USP14	hsa-miR-126-5p	92.6453	NM_005151
USP14	hsa-miR-143-5p	92.5675	NM_001037334
USP14	hsa-miR-4696	92.0888	NM_001037334
USP14	hsa-miR-3120-3p	91.9394	NM_001037334
USP14	hsa-miR-596	89.6464	NM_001037334
USP14	hsa-miR-11181-5p	89.5288	NM_005151
USP14	hsa-miR-4256	89.5288	NM_005151
USP14	hsa-miR-1250-3p	89.2653	NM_005151
USP14	hsa-miR-6839-5p	88.2103	NM_005151
USP14	hsa-miR-5088-5p	88.0795	NM_005151
USP14	hsa-miR-450a-2-3p	88.0188	NM_005151
USP14	hsa-miR-6852-3p	87.9133	NM_005151
USP14	hsa-miR-1224-3p	87.5912	NM_001037334
USP14	hsa-miR-378j	87.266	NM_005151
USP14	hsa-miR-4729	85.2385	NM_001037334
USP14	hsa-miR-5582-5p	84.4591	NM_001037334
USP14	hsa-miR-6736-5p	83.708	NM_005151
USP14	hsa-miR-4701-3p	83.708	NM_005151
USP14	hsa-miR-1262	83.708	NM_005151
USP14	hsa-miR-5006-3p	83.5689	NM_001037334
USP14	hsa-miR-4755-5p	83.5689	NM_001037334
USP14	hsa-miR-4528	83.3427	NM_005151
USP14	hsa-miR-6505-5p	82.75	NM_001037334
USP14	hsa-miR-7-1-3p	82.618	NM_005151
USP14	hsa-miR-7-2-3p	82.618	NM_005151
USP14	hsa-miR-4773	80.1925	NM_001037334

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Motifs and transcription factors (TFs) regulating USP14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP14	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
USP14	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
USP14	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
USP14	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
USP14	metacluster_3.14	WT1; WT1 (directAnnotation).
USP14	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
USP14	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
USP14	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
USP14	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
USP14	metacluster_7.13	ZFX (directAnnotation).
USP14	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
USP14	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
USP14	transfac_pro__M01175	ZBTB7B (directAnnotation).
USP14	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
USP14	tfdimers__MD00151	CHURC1 (directAnnotation).
USP14	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
USP14	transfac_pro__M01303	SP1 (directAnnotation).
USP14	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP14	transfac_pro__M02090	E2F4 (directAnnotation).
USP14	transfac_pro__M01714	KLF15 (directAnnotation).
USP14	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
USP14	transfac_pro__M02281	SP1 (directAnnotation).
USP14	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
USP14	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
USP14	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
USP14	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
USP14	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
USP14	transfac_pro__M00652	NRF1 (directAnnotation).
USP14	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
USP14	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
USP14	hdpi__TIMELESS	TIMELESS (directAnnotation).
USP14	transfac_pro__M06340	ZNF790 (directAnnotation).
USP14	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
USP14	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP14	metacluster_160.20	JUND; PRDM15 (directAnnotation).
USP14	cisbp__M00341	PAX6 (directAnnotation).
USP14	metacluster_175.1	ZNF283 (directAnnotation).
USP14	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
USP14	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
USP14	metacluster_151.2	ZNF23 (directAnnotation).
USP14	transfac_pro__M03806	ZBTB7C (directAnnotation).
USP14	metacluster_182.10	ZFX (directAnnotation).
USP14	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
USP14	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
USP14	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
USP14	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
USP14	jaspar__MA1650.1	ZBTB14 (directAnnotation).
USP14	transfac_pro__M06085	ZNF26 (directAnnotation).
USP14	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
USP14	"Phenethyl Isothiocyanate"	DB12695	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."