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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP10

Summary for USP10

Gene information	Gene symbol	USP10
	Ensembl ID	ENSG00000103194
	Entrez ID	9100
	Gene name	ubiquitin specific peptidase 10
	Synonyms	KIAA0190\|UBPO
	Gene type	protein_coding
	UniProtAcc	Q14694

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Dataset with differentially expressed gene: USP10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.598051	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.281771	6.82e-12
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.335879	2.91e-15
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.7803	2.18e-18
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.295543	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.840324	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.341982	0.00e+00

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Expression of USP10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP10	hsa-miR-3177-5p	99.6485	NM_001272075
USP10	hsa-miR-149-5p	96.2716	NM_001272075
USP10	hsa-miR-7157-5p	95.4791	NM_001272075
USP10	hsa-miR-4310	95.2554	NM_001272075
USP10	hsa-miR-374a-3p	95.0813	NM_001272075
USP10	hsa-miR-138-5p	95.0069	NM_001272075
USP10	hsa-miR-3145-5p	94.6032	NM_001272075
USP10	hsa-miR-153-5p	94.4636	NM_001272075
USP10	hsa-miR-4764-3p	94.2594	NM_001272075
USP10	hsa-miR-4719	93.864	NM_001272075
USP10	hsa-miR-4477b	93.819	NM_001272075
USP10	hsa-miR-5197-5p	93.6881	NM_001272075
USP10	hsa-miR-891b	93.6718	NM_001272075
USP10	hsa-miR-9500	93.2828	NM_001272075
USP10	hsa-miR-7856-5p	92.9695	NM_001272075
USP10	hsa-miR-6833-3p	92.5508	NM_001272075
USP10	hsa-miR-519d-5p	92.0293	NM_001272075
USP10	hsa-miR-6873-3p	91.4584	NM_001272075
USP10	hsa-miR-548x-3p	90.894	NM_001272075
USP10	hsa-miR-548aj-3p	90.894	NM_001272075
USP10	hsa-miR-8070	90.7025	NM_001272075
USP10	hsa-miR-7152-5p	90.5718	NM_001272075
USP10	hsa-miR-1250-3p	90.2603	NM_001272075
USP10	hsa-miR-4768-5p	90.1717	NM_001272075
USP10	hsa-miR-335-3p	89.7162	NM_001272075
USP10	hsa-miR-892a	89.6533	NM_001272075
USP10	hsa-miR-892b	89.5186	NM_001272075
USP10	hsa-miR-548ah-3p	88.1587	NM_001272075
USP10	hsa-miR-548aq-3p	88.1587	NM_001272075
USP10	hsa-miR-548am-3p	88.1587	NM_001272075
USP10	hsa-miR-548ae-3p	88.1587	NM_001272075
USP10	hsa-miR-548j-3p	88.1587	NM_001272075
USP10	hsa-miR-5010-3p	87.8792	NM_001272075
USP10	hsa-miR-922	86.5903	NM_001272075
USP10	hsa-miR-205-3p	86.2685	NM_001272075
USP10	hsa-miR-634	85.5645	NM_001272075
USP10	hsa-miR-4729	82.7268	NM_001272075
USP10	hsa-miR-3613-3p	81.8892	NM_001272075
USP10	hsa-miR-126-5p	81.191	NM_001272075
USP10	hsa-miR-4468	81.1051	NM_001272075
USP10	hsa-miR-595	80.7239	NM_001272075

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Motifs and transcription factors (TFs) regulating USP10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP10	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
USP10	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
USP10	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
USP10	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
USP10	transfac_pro__M04950	EGR1 (directAnnotation).
USP10	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
USP10	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
USP10	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
USP10	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
USP10	transfac_pro__M00652	NRF1 (directAnnotation).
USP10	hdpi__ETV4	ETV4 (directAnnotation).
USP10	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
USP10	transfac_pro__M04866	HDAC2 (directAnnotation).
USP10	jaspar__MA1122.1	TFDP1 (directAnnotation).
USP10	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
USP10	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
USP10	transfac_pro__M01182	HINFP (directAnnotation).
USP10	jaspar__MA1933.1	SREBF2 (directAnnotation).
USP10	cisbp__M02645	ETS1 (directAnnotation).
USP10	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
USP10	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
USP10	metacluster_135.11	NR2C2 (directAnnotation).
USP10	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP10	tfdimers__MD00038	TFAP2C (directAnnotation).
USP10	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
USP10	metacluster_7.13	ZFX (directAnnotation).
USP10	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
USP10	cisbp__M00968	MTF2 (directAnnotation).
USP10	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP10	metacluster_160.20	JUND; PRDM15 (directAnnotation).
USP10	cisbp__M00341	PAX6 (directAnnotation).
USP10	metacluster_198.3	ZFP64 (directAnnotation).
USP10	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP10	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
USP10	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
USP10	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
USP10	cisbp__M00788	ZFY (inferredBy_Orthology).
USP10	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
USP10	metacluster_175.1	ZNF283 (directAnnotation).
USP10	hdpi__ZNF304	ZNF304 (directAnnotation).
USP10	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
USP10	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
USP10	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
USP10	transfac_pro__M01199	TRIM28 (directAnnotation).
USP10	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
USP10	metacluster_151.2	ZNF23 (directAnnotation).
USP10	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP10	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
USP10	transfac_pro__M03806	ZBTB7C (directAnnotation).
USP10	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."