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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UNK

Summary for UNK

Gene information	Gene symbol	UNK
	Ensembl ID	ENSG00000132478
	Entrez ID	85451
	Gene name	unk zinc finger
	Synonyms	KIAA1753\|ZC3H5\|ZC3HDC5
	Gene type	protein_coding
	UniProtAcc	Q9C0B0

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Dataset with differentially expressed gene: UNK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.899272	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.271435	1.19e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.259439	8.81e-12

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Expression of UNK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UNK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UNK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UNK	hsa-miR-5011-5p	100	NM_001080419
UNK	hsa-miR-190a-3p	99.9999	NM_001080419
UNK	hsa-miR-12136	96.6416	NM_001080419
UNK	hsa-miR-5580-3p	95.6615	NM_001080419
UNK	hsa-miR-6507-3p	94.94	NM_001080419
UNK	hsa-miR-155-3p	93.7085	NM_001080419
UNK	hsa-miR-6867-5p	92.1665	NM_001080419
UNK	hsa-miR-3173-5p	91.4818	NM_001080419
UNK	hsa-miR-6799-3p	90.5689	NM_001080419
UNK	hsa-miR-4659b-3p	90.3586	NM_001080419
UNK	hsa-miR-4659a-3p	90.3586	NM_001080419
UNK	hsa-miR-1207-5p	90.1643	NM_001080419
UNK	hsa-miR-589-3p	89.3592	NM_001080419
UNK	hsa-miR-4670-3p	89.1177	NM_001080419
UNK	hsa-let-7g-3p	87.985	NM_001080419
UNK	hsa-let-7a-2-3p	87.985	NM_001080419
UNK	hsa-miR-4763-3p	87.0019	NM_001080419
UNK	hsa-miR-3685	86.1059	NM_001080419
UNK	hsa-miR-129-1-3p	85.8126	NM_001080419
UNK	hsa-miR-129-2-3p	85.8126	NM_001080419
UNK	hsa-miR-3680-3p	85.7133	NM_001080419
UNK	hsa-miR-106b-5p	85.1117	NM_001080419
UNK	hsa-miR-20a-5p	85.1117	NM_001080419
UNK	hsa-miR-20b-5p	85.0309	NM_001080419
UNK	hsa-miR-526b-3p	85.0309	NM_001080419
UNK	hsa-miR-93-5p	85.0309	NM_001080419
UNK	hsa-miR-17-5p	85.0309	NM_001080419
UNK	hsa-miR-519d-3p	85.0309	NM_001080419
UNK	hsa-miR-106a-5p	85.0309	NM_001080419
UNK	hsa-miR-1468-3p	84.4658	NM_001080419
UNK	hsa-miR-22-3p	84.1356	NM_001080419
UNK	hsa-miR-1264	83.8801	NM_001080419
UNK	hsa-miR-3663-3p	83.8025	NM_001080419
UNK	hsa-miR-1233-5p	83.6616	NM_001080419
UNK	hsa-miR-6778-5p	83.6616	NM_001080419
UNK	hsa-miR-7160-3p	83.3008	NM_001080419
UNK	hsa-miR-4796-5p	82.25	NM_001080419
UNK	hsa-miR-4789-3p	81.0878	NM_001080419
UNK	hsa-miR-4749-3p	81.0804	NM_001080419
UNK	hsa-miR-5571-3p	80.6893	NM_001080419

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Motifs and transcription factors (TFs) regulating UNK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UNK	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
UNK	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
UNK	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
UNK	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
UNK	transfac_pro__M04950	EGR1 (directAnnotation).
UNK	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
UNK	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
UNK	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
UNK	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
UNK	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
UNK	transfac_pro__M00652	NRF1 (directAnnotation).
UNK	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
UNK	transfac_pro__M04866	HDAC2 (directAnnotation).
UNK	jaspar__MA1122.1	TFDP1 (directAnnotation).
UNK	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
UNK	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
UNK	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
UNK	jaspar__MA1708.1	ETV7 (directAnnotation).
UNK	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
UNK	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
UNK	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
UNK	metacluster_81.7	CREB1 (directAnnotation).
UNK	cisbp__M08198	ELF1 (directAnnotation).
UNK	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
UNK	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
UNK	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
UNK	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."