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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UNC5B

Summary for UNC5B

Gene information	Gene symbol	UNC5B
	Ensembl ID	ENSG00000107731
	Entrez ID	219699
	Gene name	unc-5 netrin receptor B
	Synonyms	p53RDL1\|UNC5H2
	Gene type	protein_coding
	UniProtAcc	Q8IZJ1

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Dataset with differentially expressed gene: UNC5B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.32542	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-1.39775	0.00e+00

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Expression of UNC5B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UNC5B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UNC5B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UNC5B	hsa-miR-8485	99.8451	NM_001244889
UNC5B	hsa-miR-4731-5p	96.1699	NM_001244889
UNC5B	hsa-miR-765	94.1775	NM_001244889
UNC5B	hsa-miR-12124	93.4705	NM_001244889
UNC5B	hsa-miR-11181-3p	93.2989	NM_001244889
UNC5B	hsa-miR-6804-5p	92.5728	NM_001244889
UNC5B	hsa-miR-665	91.6896	NM_001244889
UNC5B	hsa-miR-12135	90.1958	NM_001244889
UNC5B	hsa-miR-6854-3p	89.5198	NM_001244889
UNC5B	hsa-miR-4755-3p	89.5034	NM_001244889
UNC5B	hsa-miR-548as-3p	88.9043	NM_001244889
UNC5B	hsa-miR-6839-5p	88.8507	NM_001244889
UNC5B	hsa-miR-4728-5p	88.8477	NM_001244889
UNC5B	hsa-miR-8089	87.0328	NM_001244889
UNC5B	hsa-miR-378j	86.4796	NM_001244889
UNC5B	hsa-miR-6785-5p	86.1387	NM_001244889
UNC5B	hsa-miR-7110-3p	85.2694	NM_001244889
UNC5B	hsa-miR-2110	85.1723	NM_001244889
UNC5B	hsa-miR-4700-5p	84.9859	NM_001244889
UNC5B	hsa-miR-4667-5p	84.9151	NM_001244889
UNC5B	hsa-miR-6756-5p	84.4379	NM_001244889
UNC5B	hsa-miR-6828-5p	83.8897	NM_001244889
UNC5B	hsa-miR-4483	83.827	NM_001244889
UNC5B	hsa-miR-149-3p	83.5624	NM_001244889
UNC5B	hsa-miR-6883-5p	83.5624	NM_001244889
UNC5B	hsa-miR-5706	83.1712	NM_001244889
UNC5B	hsa-miR-4782-5p	83.1712	NM_001244889
UNC5B	hsa-miR-4725-3p	82.8332	NM_001244889
UNC5B	hsa-miR-6780b-5p	82.8332	NM_001244889
UNC5B	hsa-miR-6890-3p	82.349	NM_001244889
UNC5B	hsa-miR-1261	82.098	NM_001244889
UNC5B	hsa-miR-7850-5p	81.8607	NM_001244889
UNC5B	hsa-miR-3162-5p	81.2706	NM_001244889
UNC5B	hsa-miR-6825-5p	81.0366	NM_001244889

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Motifs and transcription factors (TFs) regulating UNC5B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UNC5B	transfac_pro__M03813	POU3F3 (directAnnotation).
UNC5B	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
UNC5B	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
UNC5B	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
UNC5B	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
UNC5B	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
UNC5B	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
UNC5B	metacluster_52.11	ZNF184 (directAnnotation).
UNC5B	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
UNC5B	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."