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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ULK2

Summary for ULK2

Gene information	Gene symbol	ULK2
	Ensembl ID	ENSG00000083290
	Entrez ID	9706
	Gene name	unc-51 like autophagy activating kinase 2
	Synonyms	ATG1B\|KIAA0623\|Unc51.2
	Gene type	protein_coding
	UniProtAcc	Q8IYT8

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Dataset with differentially expressed gene: ULK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.258609	1.72e-18

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Expression of ULK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ULK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ULK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ULK2	hsa-miR-1297	98.6864	NM_014683
ULK2	hsa-miR-26a-5p	98.5327	NM_014683
ULK2	hsa-miR-26b-5p	98.5327	NM_014683
ULK2	hsa-miR-4465	98.2791	NM_014683
ULK2	hsa-miR-541-5p	98.2381	NM_014683
ULK2	hsa-miR-3159	97.9383	NM_014683
ULK2	hsa-miR-323a-3p	97.2891	NM_014683
ULK2	hsa-miR-4671-3p	97.0046	NM_014683
ULK2	hsa-miR-4699-5p	96.7101	NM_014683
ULK2	hsa-miR-12123	95.9582	NM_014683
ULK2	hsa-miR-515-5p	95.7579	NM_014683
ULK2	hsa-miR-519e-5p	95.7579	NM_014683
ULK2	hsa-miR-3685	95.6196	NM_014683
ULK2	hsa-miR-130b-3p	95.3276	NM_014683
ULK2	hsa-miR-454-3p	95.092	NM_014683
ULK2	hsa-miR-130a-3p	94.8318	NM_014683
ULK2	hsa-miR-3666	94.8318	NM_014683
ULK2	hsa-miR-301b-3p	94.8318	NM_014683
ULK2	hsa-miR-301a-3p	94.8318	NM_014683
ULK2	hsa-miR-4295	94.8318	NM_014683
ULK2	hsa-miR-5697	94.4849	NM_014683
ULK2	hsa-miR-155-3p	93.9697	NM_014683
ULK2	hsa-miR-4473	93.1575	NM_014683
ULK2	hsa-miR-550b-2-5p	92.7304	NM_014683
ULK2	hsa-miR-105-5p	92.6785	NM_001142610
ULK2	hsa-miR-7853-5p	92.6785	NM_001142610
ULK2	hsa-miR-4677-5p	92.4319	NM_014683
ULK2	hsa-miR-577	92.2671	NM_014683
ULK2	hsa-miR-6875-3p	91.8038	NM_014683
ULK2	hsa-miR-3714	91.6275	NM_014683
ULK2	hsa-miR-3613-3p	90.4767	NM_014683
ULK2	hsa-miR-323b-3p	90.4357	NM_014683
ULK2	hsa-miR-4272	89.9218	NM_014683
ULK2	hsa-miR-381-3p	89.3084	NM_014683
ULK2	hsa-miR-300	89.3084	NM_014683
ULK2	hsa-miR-1249-5p	89.0867	NM_014683
ULK2	hsa-miR-2681-5p	89.0802	NM_014683
ULK2	hsa-miR-7852-3p	88.7274	NM_014683
ULK2	hsa-miR-6511a-5p	88.6741	NM_014683
ULK2	hsa-miR-6507-5p	88.5737	NM_014683
ULK2	hsa-miR-5700	88.5675	NM_014683
ULK2	hsa-miR-506-3p	88.0301	NM_014683
ULK2	hsa-miR-124-3p	88.0301	NM_014683
ULK2	hsa-miR-9-5p	87.9215	NM_014683
ULK2	hsa-miR-6797-5p	87.9074	NM_014683
ULK2	hsa-miR-429	87.4852	NM_014683
ULK2	hsa-miR-200b-3p	87.4852	NM_014683
ULK2	hsa-miR-200c-3p	87.4852	NM_014683
ULK2	hsa-miR-3910	86.8671	NM_014683
ULK2	hsa-miR-5683	86.7799	NM_014683

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Motifs and transcription factors (TFs) regulating ULK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ULK2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ULK2	metacluster_7.13	ZFX (directAnnotation).
ULK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ULK2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ULK2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ULK2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ULK2	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ULK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."