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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UHMK1

Summary for UHMK1

Gene information	Gene symbol	UHMK1
	Ensembl ID	ENSG00000152332
	Entrez ID	127933
	Gene name	U2AF homology motif kinase 1
	Synonyms	KIS\|Kist
	Gene type	protein_coding
	UniProtAcc	Q8TAS1

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Dataset with differentially expressed gene: UHMK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.324549	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.271396	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.500903	1.63e-29
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.519176	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.03885	0.00e+00

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Expression of UHMK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UHMK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UHMK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UHMK1	hsa-miR-3658	98.6791	NM_144624
UHMK1	hsa-miR-545-3p	98.173	NM_144624
UHMK1	hsa-miR-148b-3p	98.015	NM_144624
UHMK1	hsa-miR-152-3p	98.015	NM_144624
UHMK1	hsa-miR-148a-3p	98.015	NM_144624
UHMK1	hsa-miR-373-5p	97.4605	NM_001184763
UHMK1	hsa-miR-616-5p	97.4605	NM_001184763
UHMK1	hsa-miR-371b-5p	97.4605	NM_001184763
UHMK1	hsa-miR-6833-3p	97.3036	NM_144624
UHMK1	hsa-miR-4768-5p	97.1714	NM_144624
UHMK1	hsa-miR-9-5p	96.9952	NM_144624
UHMK1	hsa-miR-3977	96.3855	NM_144624
UHMK1	hsa-miR-3613-3p	95.7687	NM_144624
UHMK1	hsa-miR-4524b-5p	95.7531	NM_144624
UHMK1	hsa-miR-4524a-5p	95.7531	NM_144624
UHMK1	hsa-miR-3163	95.432	NM_144624
UHMK1	hsa-miR-12119	94.9661	NM_001184763
UHMK1	hsa-miR-4291	94.9011	NM_144624
UHMK1	hsa-miR-3529-3p	94.6917	NM_144624
UHMK1	hsa-miR-4784	94.5839	NM_144624
UHMK1	hsa-miR-3150b-3p	94.5839	NM_144624
UHMK1	hsa-miR-5692a	94.2725	NM_144624
UHMK1	hsa-miR-4282	94.1015	NM_001184763
UHMK1	hsa-miR-29b-2-5p	93.1244	NM_144624
UHMK1	hsa-miR-5680	93.0906	NM_144624
UHMK1	hsa-miR-1825	92.1958	NM_144624
UHMK1	hsa-miR-1248	91.828	NM_001184763
UHMK1	hsa-miR-9500	90.2895	NM_001184763
UHMK1	hsa-miR-3159	88.4909	NM_144624
UHMK1	hsa-miR-4650-3p	87.9904	NM_144624
UHMK1	hsa-miR-4768-3p	87.6707	NM_001184763
UHMK1	hsa-miR-7162-3p	87.4313	NM_144624
UHMK1	hsa-miR-19a-3p	86.8262	NM_144624
UHMK1	hsa-miR-19b-3p	86.8262	NM_144624
UHMK1	hsa-miR-450a-1-3p	86.2345	NM_001184763
UHMK1	hsa-miR-5002-5p	85.7967	NM_144624
UHMK1	hsa-miR-216b-3p	85.7702	NM_001184763
UHMK1	hsa-miR-7854-3p	85.143	NM_144624
UHMK1	hsa-miR-4470	84.9302	NM_001184763
UHMK1	hsa-miR-548x-3p	84.8312	NM_001184763
UHMK1	hsa-miR-548aj-3p	84.8312	NM_001184763
UHMK1	hsa-miR-646	84.3473	NM_144624
UHMK1	hsa-miR-433-3p	84.263	NM_001184763
UHMK1	hsa-miR-3194-5p	83.7286	NM_144624
UHMK1	hsa-miR-3617-3p	83.6876	NM_001184763
UHMK1	hsa-miR-548p	83.3382	NM_144624
UHMK1	hsa-miR-548d-3p	82.9167	NM_001184763
UHMK1	hsa-miR-548z	82.9167	NM_001184763
UHMK1	hsa-miR-548ac	82.9167	NM_001184763
UHMK1	hsa-miR-548bb-3p	82.9167	NM_001184763

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Motifs and transcription factors (TFs) regulating UHMK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UHMK1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."