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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: UGGT1

Summary for UGGT1

Gene informationGene symbol

UGGT1

Ensembl ID

ENSG00000136731

Entrez ID

56886

Gene nameUDP-glucose glycoprotein glucosyltransferase 1
SynonymsHUGT1|UGCGL1
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: UGGT1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.6189160.00e+00

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Expression of UGGT1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to UGGT1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UGGT1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
UGGT1hsa-miR-7162-3p99.6012NM_020120
UGGT1hsa-miR-548x-3p94.1662NM_020120
UGGT1hsa-miR-548aj-3p94.1662NM_020120
UGGT1hsa-miR-335-3p94.1107NM_020120
UGGT1hsa-miR-429194.0695NM_020120
UGGT1hsa-miR-548g-3p91.7877NM_020120
UGGT1hsa-miR-60791.4287NM_020120
UGGT1hsa-miR-548ah-3p91.3408NM_020120
UGGT1hsa-miR-548ae-3p91.3408NM_020120
UGGT1hsa-miR-548j-3p91.3408NM_020120
UGGT1hsa-miR-548am-3p91.3408NM_020120
UGGT1hsa-miR-548aq-3p91.3408NM_020120
UGGT1hsa-miR-4693-5p91.3134NM_020120
UGGT1hsa-miR-101-3p91.2785NM_020120
UGGT1hsa-miR-548e-3p90.8372NM_020120
UGGT1hsa-miR-548bc90.8372NM_020120
UGGT1hsa-miR-548ar-3p90.8372NM_020120
UGGT1hsa-miR-548f-3p90.8372NM_020120
UGGT1hsa-miR-548a-3p90.8372NM_020120
UGGT1hsa-miR-548az-3p90.8372NM_020120
UGGT1hsa-miR-6778-3p89.0005NM_020120
UGGT1hsa-miR-316688.8435NM_020120
UGGT1hsa-miR-548e-5p87.8595NM_020120
UGGT1hsa-miR-3158-5p87.4529NM_020120
UGGT1hsa-miR-314887.1648NM_020120
UGGT1hsa-miR-3059-5p87.0967NM_020120
UGGT1hsa-miR-6881-3p86.4158NM_020120
UGGT1hsa-miR-4742-5p85.8275NM_020120
UGGT1hsa-miR-4649-3p84.7396NM_020120
UGGT1hsa-miR-2276-5p84.4964NM_020120
UGGT1hsa-miR-651-3p82.8948NM_020120
UGGT1hsa-miR-6832-5p82.8382NM_020120
UGGT1hsa-miR-477581.9884NM_020120
UGGT1hsa-miR-313381.8667NM_020120
UGGT1hsa-miR-105-5p81.7573NM_020120
UGGT1hsa-miR-7853-5p81.7573NM_020120
UGGT1hsa-miR-3617-3p81.4151NM_020120
UGGT1hsa-miR-6780a-3p81.3972NM_020120
UGGT1hsa-miR-7-5p80.9034NM_020120
UGGT1hsa-miR-5197-3p80.4722NM_020120
UGGT1hsa-miR-186-5p80.0974NM_020120
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Motifs and transcription factors (TFs) regulating UGGT1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."