Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: UCK2

Summary for UCK2

Gene information	Gene symbol	UCK2
	Ensembl ID	ENSG00000143179
	Entrez ID	7371
	Gene name	uridine-cytidine kinase 2
	Synonyms	UMPK
	Gene type	protein_coding
	UniProtAcc	Q9BZX2

Top

Dataset with differentially expressed gene: UCK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.415742	2.07e-21
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.415933	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.482735	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.403447	4.62e-36
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.452883	3.06e-28
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.330706	2.92e-16
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.325308	2.44e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.29447	1.68e-44

Top

Expression of UCK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to UCK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating UCK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UCK2	hsa-miR-432-5p	96.6872	NM_012474
UCK2	hsa-miR-4319	95.8642	NM_012474
UCK2	hsa-miR-125b-5p	94.4036	NM_012474
UCK2	hsa-miR-125a-5p	94.4036	NM_012474
UCK2	hsa-miR-4267	94.0935	NM_012474
UCK2	hsa-miR-190a-3p	93.1789	NM_012474
UCK2	hsa-miR-4715-5p	92.8389	NM_012474
UCK2	hsa-miR-548av-5p	92.7955	NM_012474
UCK2	hsa-miR-548k	92.7955	NM_012474
UCK2	hsa-miR-8054	92.7955	NM_012474
UCK2	hsa-miR-4667-3p	90.851	NM_012474
UCK2	hsa-miR-144-3p	89.7397	NM_012474
UCK2	hsa-miR-1297	89.5118	NM_012474
UCK2	hsa-miR-6795-5p	89.4506	NM_012474
UCK2	hsa-miR-6887-5p	89.4506	NM_012474
UCK2	hsa-miR-302a-5p	88.684	NM_012474
UCK2	hsa-let-7a-2-3p	88.316	NM_012474
UCK2	hsa-let-7g-3p	88.316	NM_012474
UCK2	hsa-miR-4483	87.831	NM_012474
UCK2	hsa-miR-888-5p	87.5588	NM_012474
UCK2	hsa-miR-4672	86.5401	NM_012474
UCK2	hsa-miR-3941	86.3785	NM_012474
UCK2	hsa-miR-582-3p	86.1895	NM_012474
UCK2	hsa-miR-371b-5p	85.5975	NM_012474
UCK2	hsa-miR-616-5p	85.5975	NM_012474
UCK2	hsa-miR-373-5p	85.5975	NM_012474
UCK2	hsa-miR-4801	84.539	NM_012474
UCK2	hsa-miR-6721-5p	84.2392	NM_012474
UCK2	hsa-miR-5011-5p	84.1323	NM_012474
UCK2	hsa-miR-4496	84.0311	NM_012474
UCK2	hsa-miR-96-5p	83.8679	NM_012474
UCK2	hsa-miR-466	83.3647	NM_012474
UCK2	hsa-miR-1271-5p	83.3372	NM_012474
UCK2	hsa-miR-12133	83.3372	NM_012474
UCK2	hsa-miR-493-5p	82.7349	NM_012474
UCK2	hsa-miR-26b-5p	81.9581	NM_012474
UCK2	hsa-miR-26a-5p	81.9581	NM_012474
UCK2	hsa-miR-3910	81.5851	NM_012474
UCK2	hsa-miR-4465	81.5053	NM_012474
UCK2	hsa-miR-548an	81.4771	NM_012474
UCK2	hsa-miR-4731-3p	80.9214	NM_012474
UCK2	hsa-miR-6777-3p	80.1211	NM_012474
UCK2	hsa-miR-1293	80.1141	NM_012474

Page: 1

Top

Motifs and transcription factors (TFs) regulating UCK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UCK2	metacluster_7.13	ZFX (directAnnotation).
UCK2	metacluster_151.2	ZNF23 (directAnnotation).
UCK2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UCK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UCK2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
UCK2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UCK2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
UCK2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
UCK2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
UCK2	transfac_pro__M04950	EGR1 (directAnnotation).
UCK2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
UCK2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
UCK2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
UCK2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UCK2	transfac_pro__M00652	NRF1 (directAnnotation).
UCK2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
UCK2	transfac_pro__M04866	HDAC2 (directAnnotation).
UCK2	jaspar__MA1122.1	TFDP1 (directAnnotation).
UCK2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
UCK2	cisbp__M08198	ELF1 (directAnnotation).
UCK2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
UCK2	hdpi__ELF2	ELF2 (directAnnotation).
UCK2	metacluster_183.4	ETS1 (inferredBy_Orthology).
UCK2	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
UCK2	transfac_pro__M04862	NRF1 (directAnnotation).
UCK2	metacluster_81.7	CREB1 (directAnnotation).
UCK2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
UCK2	transfac_pro__M00492	STAT1 (directAnnotation).
UCK2	transfac_pro__M04848	TAF1 (directAnnotation).
UCK2	transfac_pro__M05544	BCL11A (directAnnotation).
UCK2	metacluster_165.3	HOMEZ; HOMEZ; HOMEZ (directAnnotation).
UCK2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
UCK2	"Cytidine"	DB02097	small molecule
UCK2	"Cytidine-5'-Monophosphate"	DB03403	small molecule
UCK2	"Cytidine-5'-Triphosphate"	DB02431	small molecule
UCK2	"Uridine 5'-triphosphate"	DB04005	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."