Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: UCHL1

Summary for UCHL1

Gene information	Gene symbol	UCHL1
	Ensembl ID	ENSG00000154277
	Entrez ID	7345
	Gene name	ubiquitin C-terminal hydrolase L1
	Synonyms	PARK5\|PGP9.5\|Uch-L1\|UCHL-1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: UCHL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.925915	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.610022	3.29e-27
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.990657	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-1.30604	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.279063	0.00e+00

Top

Expression of UCHL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to UCHL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating UCHL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UCHL1	hsa-miR-922	94.3351	NM_004181
UCHL1	hsa-miR-6864-5p	92.6657	NM_004181
UCHL1	hsa-miR-3158-5p	89.4147	NM_004181
UCHL1	hsa-miR-4291	87.4315	NM_004181
UCHL1	hsa-miR-600	85.7896	NM_004181
UCHL1	hsa-miR-5004-5p	85.3667	NM_004181
UCHL1	hsa-miR-125b-2-3p	83.563	NM_004181
UCHL1	hsa-miR-7515	83.2487	NM_004181
UCHL1	hsa-miR-3617-3p	82.4823	NM_004181

Page: 1

Top

Motifs and transcription factors (TFs) regulating UCHL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UCHL1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
UCHL1	transfac_pro__M05846	ZNF689 (directAnnotation).
UCHL1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
UCHL1	metacluster_33.5	MTF1 (inferredBy_Orthology).
UCHL1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
UCHL1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
UCHL1	metacluster_22.29	NFE2 (directAnnotation).
UCHL1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
UCHL1	metacluster_22.13	MAFK (inferredBy_Orthology).
UCHL1	transfac_pro__M06643	ZNF583 (directAnnotation).
UCHL1	metacluster_22.32	NFE2L2 (directAnnotation).
UCHL1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
UCHL1	metacluster_22.25	NFE2L2 (directAnnotation).
UCHL1	transfac_pro__M01298	MECP2 (directAnnotation).
UCHL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
UCHL1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
UCHL1	taipale_cyt_meth__PITX2_YTAATCCN_FL	PITX2 (directAnnotation).
UCHL1	transfac_pro__M04950	EGR1 (directAnnotation).
UCHL1	metacluster_55.5	ZNF541 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
UCHL1	"Phenethyl Isothiocyanate"	DB12695	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."