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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBP1

Summary for UBP1

Gene information	Gene symbol	UBP1
	Ensembl ID	ENSG00000153560
	Entrez ID	7342
	Gene name	upstream binding protein 1
	Synonyms	LBP-1a
	Gene type	protein_coding
	UniProtAcc	Q9NZI7

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Dataset with differentially expressed gene: UBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.443715	0.00e+00

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Expression of UBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBP1	hsa-miR-4262	96.7937	NM_001128160
UBP1	hsa-miR-3085-5p	96.6398	NM_001128160
UBP1	hsa-miR-5002-5p	95.5289	NM_001128161
UBP1	hsa-miR-1305	95.1062	NM_001128160
UBP1	hsa-miR-181d-5p	94.8941	NM_001128160
UBP1	hsa-miR-181b-5p	94.8941	NM_001128160
UBP1	hsa-miR-181a-5p	94.8941	NM_001128160
UBP1	hsa-miR-181c-5p	94.8941	NM_001128160
UBP1	hsa-miR-449a	94.4911	NM_001128160
UBP1	hsa-miR-34a-5p	94.4911	NM_001128160
UBP1	hsa-miR-494-3p	93.8852	NM_001128160
UBP1	hsa-miR-581	93.528	NM_001128161
UBP1	hsa-miR-34c-5p	92.8849	NM_001128160
UBP1	hsa-miR-449b-5p	92.8849	NM_001128160
UBP1	hsa-miR-365a-3p	92.8796	NM_001128160
UBP1	hsa-miR-365b-3p	92.8796	NM_001128160
UBP1	hsa-miR-548p	92.8763	NM_001128161
UBP1	hsa-miR-4310	91.0216	NM_001128160
UBP1	hsa-miR-4729	89.6139	NM_001128160
UBP1	hsa-miR-570-3p	89.5806	NM_001128160
UBP1	hsa-miR-3605-5p	89.1852	NM_001128160
UBP1	hsa-miR-7157-5p	87.5771	NM_001128160
UBP1	hsa-miR-10527-5p	87.5375	NM_001128161
UBP1	hsa-miR-548au-3p	87.5144	NM_001128160
UBP1	hsa-miR-5190	87.0905	NM_001128160
UBP1	hsa-miR-122b-5p	86.9889	NM_001128160
UBP1	hsa-miR-211-5p	85.9591	NM_001128160
UBP1	hsa-miR-204-5p	85.9591	NM_001128160
UBP1	hsa-miR-138-5p	85.6615	NM_001128160
UBP1	hsa-miR-193a-3p	84.2606	NM_001128160
UBP1	hsa-miR-193b-3p	84.2606	NM_001128160
UBP1	hsa-miR-4694-3p	83.8886	NM_001128161
UBP1	hsa-miR-10524-5p	83.2737	NM_001128160
UBP1	hsa-miR-607	82.7687	NM_001128161
UBP1	hsa-miR-5000-5p	81.9952	NM_001128160
UBP1	hsa-miR-4742-5p	81.0025	NM_001128161
UBP1	hsa-miR-3192-5p	80.5496	NM_001128161
UBP1	hsa-miR-4668-3p	80.4454	NM_001128160

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Motifs and transcription factors (TFs) regulating UBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBP1	cisbp__M00341	PAX6 (directAnnotation).
UBP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UBP1	cisbp__M00788	ZFY (inferredBy_Orthology).
UBP1	metacluster_175.1	ZNF283 (directAnnotation).
UBP1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."