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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBLCP1

Summary for UBLCP1

Gene information	Gene symbol	UBLCP1
	Ensembl ID	ENSG00000164332
	Entrez ID	134510
	Gene name	ubiquitin like domain containing CTD phosphatase 1
	Synonyms	CPUB1\|MGC10067
	Gene type	protein_coding
	UniProtAcc	Q8WVY7

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Dataset with differentially expressed gene: UBLCP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.328858	2.69e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.433187	0.00e+00

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Expression of UBLCP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBLCP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBLCP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBLCP1	hsa-miR-6867-5p	100	NM_145049
UBLCP1	hsa-miR-7856-5p	97.4381	NM_145049
UBLCP1	hsa-miR-3613-3p	94.0985	NM_145049
UBLCP1	hsa-miR-676-5p	94.0557	NM_145049
UBLCP1	hsa-miR-6792-5p	93.9944	NM_145049
UBLCP1	hsa-miR-3671	93.4562	NM_145049
UBLCP1	hsa-miR-607	92.4764	NM_145049
UBLCP1	hsa-miR-3658	92.3808	NM_145049
UBLCP1	hsa-miR-548e-5p	92.3676	NM_145049
UBLCP1	hsa-miR-7-5p	89.6812	NM_145049
UBLCP1	hsa-miR-6834-3p	89.0079	NM_145049
UBLCP1	hsa-miR-338-3p	88.3403	NM_145049
UBLCP1	hsa-miR-4511	88.2754	NM_145049
UBLCP1	hsa-miR-4795-3p	86.4997	NM_145049
UBLCP1	hsa-miR-505-3p	85.9971	NM_145049
UBLCP1	hsa-miR-137-3p	85.9498	NM_145049
UBLCP1	hsa-miR-4530	85.6305	NM_145049
UBLCP1	hsa-miR-6832-3p	85.6097	NM_145049
UBLCP1	hsa-miR-29b-2-5p	83.5623	NM_145049
UBLCP1	hsa-miR-6838-3p	83.3333	NM_145049
UBLCP1	hsa-miR-6733-3p	82.2826	NM_145049
UBLCP1	hsa-miR-181a-2-3p	82.2269	NM_145049
UBLCP1	hsa-miR-548b-3p	81.8746	NM_145049
UBLCP1	hsa-miR-3163	81.8263	NM_145049
UBLCP1	hsa-miR-3140-3p	81.2896	NM_145049

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Motifs and transcription factors (TFs) regulating UBLCP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBLCP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBLCP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBLCP1	metacluster_7.13	ZFX (directAnnotation).
UBLCP1	cisbp__M00968	MTF2 (directAnnotation).
UBLCP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBLCP1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
UBLCP1	metacluster_198.3	ZFP64 (directAnnotation).
UBLCP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBLCP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBLCP1	cisbp__M00788	ZFY (inferredBy_Orthology).
UBLCP1	hdpi__ZNF304	ZNF304 (directAnnotation).
UBLCP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBLCP1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBLCP1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBLCP1	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBLCP1	jaspar__MA1933.1	SREBF2 (directAnnotation).
UBLCP1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
UBLCP1	cisbp__M01863	ZNF711 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."