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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: UBE4B

Summary for UBE4B

Gene informationGene symbol

UBE4B

Ensembl ID

ENSG00000130939

Entrez ID

10277

Gene nameubiquitination factor E4B
SynonymsE4|KIAA0684|UBOX3|UFD2
Gene typeprotein_coding
UniProtAcc

O95155


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Dataset with differentially expressed gene: UBE4B

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells0.2891554.45e-22

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostMast cells-0.6525371.41e-02

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Expression of UBE4B in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to UBE4B

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE4B

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
UBE4Bhsa-miR-6885-3p98.5582NM_001105562
UBE4Bhsa-miR-651-3p98.463NM_001105562
UBE4Bhsa-miR-15b-5p97.947NM_001105562
UBE4Bhsa-miR-15a-5p97.947NM_001105562
UBE4Bhsa-miR-16-5p97.947NM_001105562
UBE4Bhsa-miR-195-5p97.947NM_001105562
UBE4Bhsa-miR-424-5p97.5038NM_001105562
UBE4Bhsa-miR-6838-5p97.5038NM_001105562
UBE4Bhsa-miR-497-5p97.5038NM_001105562
UBE4Bhsa-miR-56796.3751NM_001105562
UBE4Bhsa-miR-612496.2372NM_001105562
UBE4Bhsa-miR-60795.91NM_001105562
UBE4Bhsa-miR-6515-5p95.64NM_001105562
UBE4Bhsa-miR-129795.0745NM_001105562
UBE4Bhsa-miR-21-3p94.8562NM_001105562
UBE4Bhsa-miR-122b-3p94.8562NM_001105562
UBE4Bhsa-miR-1249-5p94.85NM_001105562
UBE4Bhsa-miR-6797-5p94.85NM_001105562
UBE4Bhsa-miR-4524a-5p94.8195NM_001105562
UBE4Bhsa-miR-4524b-5p94.8195NM_001105562
UBE4Bhsa-miR-26b-5p94.7489NM_001105562
UBE4Bhsa-miR-26a-5p94.7489NM_001105562
UBE4Bhsa-miR-797493.3241NM_001105562
UBE4Bhsa-miR-446593.0479NM_001105562
UBE4Bhsa-miR-374b-3p92.2984NM_001105562
UBE4Bhsa-miR-503-5p92.026NM_001105562
UBE4Bhsa-miR-103a-1-5p91.5247NM_001105562
UBE4Bhsa-miR-103a-2-5p91.5247NM_001105562
UBE4Bhsa-miR-4690-5p91.3466NM_001105562
UBE4Bhsa-miR-6847-5p91.1085NM_001105562
UBE4Bhsa-miR-64690.3106NM_001105562
UBE4Bhsa-miR-374c-5p88.7303NM_001105562
UBE4Bhsa-miR-655-3p88.7303NM_001105562
UBE4Bhsa-miR-426888.4002NM_001105562
UBE4Bhsa-miR-148a-3p88.3889NM_001105562
UBE4Bhsa-miR-152-3p88.3889NM_001105562
UBE4Bhsa-miR-148b-3p88.3889NM_001105562
UBE4Bhsa-miR-4762-5p88.2594NM_001105562
UBE4Bhsa-miR-501-5p87.4431NM_001105562
UBE4Bhsa-miR-95-3p87.2267NM_001105562
UBE4Bhsa-miR-6798-3p86.6717NM_001105562
UBE4Bhsa-miR-569786.3815NM_001105562
UBE4Bhsa-miR-1277-5p86.2692NM_001105562
UBE4Bhsa-miR-545-3p86.1743NM_001105562
UBE4Bhsa-miR-5699-5p86.1021NM_001105562
UBE4Bhsa-miR-668-3p85.8987NM_001105562
UBE4Bhsa-miR-450184.6511NM_001105562
UBE4Bhsa-miR-4668-5p84.3363NM_001105562
UBE4Bhsa-miR-6715b-5p83.9751NM_001105562
UBE4Bhsa-miR-500a-5p83.8272NM_001105562
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Motifs and transcription factors (TFs) regulating UBE4B

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
UBE4Bdbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1GMEB1 (directAnnotation).
UBE4Bmetacluster_7.13ZFX (directAnnotation).
UBE4Btfdimers__MD00154MZF1; SREBF1 (directAnnotation).
UBE4Bkznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
UBE4Btransfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBE4Btaipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
UBE4Bkznf__ZNF571_Imbeault2017_OM_RCADEZNF571 (directAnnotation).
UBE4Btfdimers__MD00007E2F1; IRF8 (directAnnotation).
UBE4Btransfac_pro__M01783SP2 (directAnnotation).
UBE4Btransfac_pro__M06510ZFP62 (directAnnotation).
UBE4Bmetacluster_3.8SP5 (inferredBy_Orthology).
UBE4Bnitta__sens_TATGCT40NACT_KAA_AATAAATCACTGCA_m1_c3GFI1 (inferredBy_Orthology).
UBE4Btransfac_pro__M06622ZNF681 (directAnnotation).
UBE4Btransfac_pro__M06487ZNF695 (directAnnotation).
UBE4Btransfac_pro__M06322ZNF181 (directAnnotation).
UBE4Btransfac_pro__M05690ZNF20 (directAnnotation).
UBE4Btransfac_pro__M05513ZNF641 (inferredBy_Orthology).
UBE4Bmetacluster_117.1GATA1; GATA1 (directAnnotation). GATA1; GATA1; GATA4; GATA4 (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."