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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE3B

Summary for UBE3B

Gene information	Gene symbol	UBE3B
	Ensembl ID	ENSG00000151148
	Entrez ID	89910
	Gene name	ubiquitin protein ligase E3B
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q7Z3V4

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Dataset with differentially expressed gene: UBE3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.503121	0.00e+00

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Expression of UBE3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE3B	hsa-miR-6783-3p	93.3522	NM_130466
UBE3B	hsa-miR-1343-3p	92.317	NM_130466
UBE3B	hsa-miR-454-3p	92.2382	NM_183415
UBE3B	hsa-miR-4295	92.0299	NM_183415
UBE3B	hsa-miR-6765-3p	92.0259	NM_130466
UBE3B	hsa-miR-4664-5p	91.7649	NM_130466
UBE3B	hsa-miR-7160-5p	91.2376	NM_130466
UBE3B	hsa-miR-301a-3p	90.3964	NM_183415
UBE3B	hsa-miR-3666	90.3964	NM_183415
UBE3B	hsa-miR-130b-3p	90.3964	NM_183415
UBE3B	hsa-miR-130a-3p	90.3964	NM_183415
UBE3B	hsa-miR-301b-3p	90.3964	NM_183415
UBE3B	hsa-miR-342-5p	89.9942	NM_130466
UBE3B	hsa-miR-5585-5p	89.6697	NM_130466
UBE3B	hsa-miR-548at-5p	89.2442	NM_001270449
UBE3B	hsa-miR-4326	88.227	NM_130466
UBE3B	hsa-miR-5590-3p	86.3127	NM_001270449
UBE3B	hsa-miR-142-5p	86.3127	NM_001270449
UBE3B	hsa-miR-4671-3p	86.1155	NM_183415
UBE3B	hsa-miR-4282	85.5191	NM_001270449
UBE3B	hsa-miR-4308	83.685	NM_130466
UBE3B	hsa-miR-3646	83.4236	NM_130466
UBE3B	hsa-miR-1827	83.3998	NM_183415
UBE3B	hsa-miR-4697-3p	83.0791	NM_130466
UBE3B	hsa-miR-587	81.023	NM_183415

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Motifs and transcription factors (TFs) regulating UBE3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE3B	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
UBE3B	hdpi__ETV4	ETV4 (directAnnotation).
UBE3B	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."