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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2V1

Summary for UBE2V1

Gene information	Gene symbol	UBE2V1
	Ensembl ID	ENSG00000244687
	Entrez ID	7335
	Gene name	ubiquitin conjugating enzyme E2 V1
	Synonyms	CROC-1\|CROC1\|UBE2V\|UEV-1\|UEV1A
	Gene type	protein_coding
	UniProtAcc	Q13404

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Dataset with differentially expressed gene: UBE2V1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.610549	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.263984	0.00e+00

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Expression of UBE2V1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2V1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2V1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2V1	hsa-miR-195-5p	97.5732	NM_001032288
UBE2V1	hsa-miR-6838-5p	97.5732	NM_001032288
UBE2V1	hsa-miR-15a-5p	97.5732	NM_001032288
UBE2V1	hsa-miR-16-5p	97.5732	NM_001032288
UBE2V1	hsa-miR-15b-5p	97.5732	NM_001032288
UBE2V1	hsa-miR-497-5p	96.7904	NM_001032288
UBE2V1	hsa-miR-424-5p	96.7904	NM_001032288
UBE2V1	hsa-miR-8087	96.7104	NM_001032288
UBE2V1	hsa-miR-548e-5p	95.5887	NM_001032288
UBE2V1	hsa-miR-4318	94.3002	NM_001032288
UBE2V1	hsa-miR-9985	94.229	NM_001032288
UBE2V1	hsa-miR-27a-3p	94.229	NM_001032288
UBE2V1	hsa-miR-27b-3p	94.229	NM_001032288
UBE2V1	hsa-miR-144-3p	93.8268	NM_001032288
UBE2V1	hsa-miR-7114-5p	93.7153	NM_001032288
UBE2V1	hsa-miR-4761-5p	93.7038	NM_001032288
UBE2V1	hsa-miR-6779-3p	93.3181	NM_001032288
UBE2V1	hsa-miR-6508-5p	93.1285	NM_001032288
UBE2V1	hsa-miR-4432	93.0595	NM_001032288
UBE2V1	hsa-miR-8067	92.3068	NM_001032288
UBE2V1	hsa-miR-3190-5p	91.67	NM_001032288
UBE2V1	hsa-miR-6880-5p	91.3022	NM_001032288
UBE2V1	hsa-miR-499a-5p	90.6597	NM_001032288
UBE2V1	hsa-miR-3688-3p	87.1036	NM_001032288
UBE2V1	hsa-miR-4460	86.8537	NM_001032288
UBE2V1	hsa-miR-8084	86.519	NM_001032288
UBE2V1	hsa-miR-3065-3p	86.4161	NM_001032288
UBE2V1	hsa-miR-3977	86.1345	NM_001032288
UBE2V1	hsa-miR-6795-3p	85.1651	NM_001032288
UBE2V1	hsa-miR-203b-5p	84.9411	NM_001032288
UBE2V1	hsa-miR-6718-5p	84.9411	NM_001032288
UBE2V1	hsa-miR-5006-5p	84.0347	NM_001032288
UBE2V1	hsa-miR-585-5p	83.6918	NM_001032288
UBE2V1	hsa-miR-513a-5p	83.5237	NM_001032288
UBE2V1	hsa-miR-4736	82.9539	NM_001032288
UBE2V1	hsa-miR-4723-5p	82.9122	NM_001032288
UBE2V1	hsa-miR-147b-5p	81.7111	NM_001032288
UBE2V1	hsa-miR-610	81.6202	NM_001032288
UBE2V1	hsa-miR-10527-5p	81.1407	NM_001032288
UBE2V1	hsa-miR-6836-5p	80.5634	NM_001032288
UBE2V1	hsa-miR-6132	80.5634	NM_001032288
UBE2V1	hsa-miR-4456	80.5439	NM_001032288
UBE2V1	hsa-miR-205-3p	80.5322	NM_001032288
UBE2V1	hsa-miR-208a-3p	80.4576	NM_001032288
UBE2V1	hsa-miR-208b-3p	80.4576	NM_001032288
UBE2V1	hsa-miR-4483	80.3425	NM_001032288
UBE2V1	hsa-miR-4261	80.222	NM_001032288

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Motifs and transcription factors (TFs) regulating UBE2V1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2V1	swissregulon__hs__SPI1	SPI1 (directAnnotation).
UBE2V1	homer__ACAGGATGTGGT_ETS_RUNX	RUNX1 (directAnnotation).
UBE2V1	tfdimers__MD00066	ELF1 (directAnnotation).
UBE2V1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBE2V1	jaspar__MA0748.2	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."