Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2Q1

Summary for UBE2Q1

Gene information	Gene symbol	UBE2Q1
	Ensembl ID	ENSG00000160714
	Entrez ID	55585
	Gene name	ubiquitin conjugating enzyme E2 Q1
	Synonyms	NICE-5\|PRO3094\|UBE2Q
	Gene type	protein_coding
	UniProtAcc	Q7Z7E8

Top

Dataset with differentially expressed gene: UBE2Q1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.260665	2.18e-07
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.300914	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.450137	3.97e-26
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.355077	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.763503	0.00e+00

Top

Expression of UBE2Q1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to UBE2Q1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating UBE2Q1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2Q1	hsa-miR-195-5p	99.294	NM_017582
UBE2Q1	hsa-miR-15a-5p	99.294	NM_017582
UBE2Q1	hsa-miR-16-5p	99.294	NM_017582
UBE2Q1	hsa-miR-15b-5p	99.294	NM_017582
UBE2Q1	hsa-miR-6720-5p	99.0836	NM_017582
UBE2Q1	hsa-miR-6512-3p	99.0836	NM_017582
UBE2Q1	hsa-miR-497-5p	99.0442	NM_017582
UBE2Q1	hsa-miR-424-5p	99.0442	NM_017582
UBE2Q1	hsa-miR-6838-5p	99.0442	NM_017582
UBE2Q1	hsa-miR-6891-5p	97.9608	NM_017582
UBE2Q1	hsa-miR-12118	97.3179	NM_017582
UBE2Q1	hsa-miR-3173-3p	97.3179	NM_017582
UBE2Q1	hsa-miR-4695-5p	94.7996	NM_017582
UBE2Q1	hsa-miR-4310	93.6078	NM_017582
UBE2Q1	hsa-miR-338-3p	92.2675	NM_017582
UBE2Q1	hsa-miR-3180-5p	92.0844	NM_017582
UBE2Q1	hsa-miR-323a-3p	91.5314	NM_017582
UBE2Q1	hsa-miR-7157-5p	90.2894	NM_017582
UBE2Q1	hsa-miR-661	89.1638	NM_017582
UBE2Q1	hsa-miR-133b	89.1356	NM_017582
UBE2Q1	hsa-miR-133a-3p	89.1356	NM_017582
UBE2Q1	hsa-miR-665	88.7755	NM_017582
UBE2Q1	hsa-miR-466	87.2312	NM_017582
UBE2Q1	hsa-miR-4530	86.3487	NM_017582
UBE2Q1	hsa-miR-6499-3p	86.1108	NM_017582
UBE2Q1	hsa-miR-186-3p	85.4283	NM_017582
UBE2Q1	hsa-miR-4643	85.3848	NM_017582
UBE2Q1	hsa-miR-4789-3p	85.3848	NM_017582
UBE2Q1	hsa-miR-6825-5p	84.8825	NM_017582
UBE2Q1	hsa-miR-6852-5p	84.3777	NM_017582
UBE2Q1	hsa-miR-4446-5p	84.1908	NM_017582
UBE2Q1	hsa-miR-2467-5p	83.6749	NM_017582
UBE2Q1	hsa-miR-607	82.9016	NM_017582
UBE2Q1	hsa-miR-4428	82.155	NM_017582
UBE2Q1	hsa-miR-6871-3p	80.6115	NM_017582
UBE2Q1	hsa-miR-485-3p	80.3196	NM_017582
UBE2Q1	hsa-miR-539-3p	80.3196	NM_017582

Page: 1

Top

Motifs and transcription factors (TFs) regulating UBE2Q1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2Q1	transfac_pro__M05628	ZNF735 (directAnnotation).
UBE2Q1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
UBE2Q1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
UBE2Q1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
UBE2Q1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
UBE2Q1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
UBE2Q1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
UBE2Q1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
UBE2Q1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
UBE2Q1	jaspar__MA1933.1	SREBF2 (directAnnotation).
UBE2Q1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
UBE2Q1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
UBE2Q1	metacluster_135.11	NR2C2 (directAnnotation).
UBE2Q1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBE2Q1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
UBE2Q1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
UBE2Q1	transfac_pro__M05976	ZNF223 (directAnnotation).
UBE2Q1	transfac_pro__M02012	HIF1A (directAnnotation).
UBE2Q1	metacluster_55.5	ZNF541 (directAnnotation).
UBE2Q1	transfac_pro__M06135	ZNF28 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."