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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2J1

Summary for UBE2J1

Gene information	Gene symbol	UBE2J1
	Ensembl ID	ENSG00000198833
	Entrez ID	51465
	Gene name	ubiquitin conjugating enzyme E2 J1
	Synonyms	CGI-76\|HSPC153\|NCUBE1\|UBC6
	Gene type	protein_coding
	UniProtAcc	Q9Y385

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Dataset with differentially expressed gene: UBE2J1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.251785	4.81e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.2683	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.251305	1.82e-24
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.29169	1.52e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.264566	2.27e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.59308	6.03e-44
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.643281	3.33e-14
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.695956	6.05e-12
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	Mono/Macro	-0.253162	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.430827	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.444809	1.13e-40
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.846827	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.419115	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.664937	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.451919	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.286378	3.58e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.311265	2.21e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.334489	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.340104	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.27574	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.743452	0.00e+00

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Expression of UBE2J1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2J1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2J1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2J1	hsa-miR-30e-5p	97.6511	NM_016021
UBE2J1	hsa-miR-30d-5p	97.6511	NM_016021
UBE2J1	hsa-miR-30a-5p	97.6511	NM_016021
UBE2J1	hsa-miR-30b-5p	97.6511	NM_016021
UBE2J1	hsa-miR-30c-5p	97.6511	NM_016021
UBE2J1	hsa-miR-30d-3p	97.3218	NM_016021
UBE2J1	hsa-miR-30a-3p	97.3218	NM_016021
UBE2J1	hsa-miR-30e-3p	97.3218	NM_016021
UBE2J1	hsa-miR-33a-3p	96.9471	NM_016021
UBE2J1	hsa-miR-936	94.5454	NM_016021
UBE2J1	hsa-miR-12122	93.4978	NM_016021
UBE2J1	hsa-miR-222-5p	93.0427	NM_016021
UBE2J1	hsa-miR-4742-3p	92.2132	NM_016021
UBE2J1	hsa-miR-6773-5p	90.0388	NM_016021
UBE2J1	hsa-miR-670-3p	90.0316	NM_016021
UBE2J1	hsa-miR-150-5p	88.9617	NM_016021
UBE2J1	hsa-miR-302e	88.0406	NM_016021
UBE2J1	hsa-miR-4713-5p	87.8934	NM_016021
UBE2J1	hsa-miR-6724-5p	87.6341	NM_016021
UBE2J1	hsa-miR-4482-3p	87.1398	NM_016021
UBE2J1	hsa-miR-1197	86.8035	NM_016021
UBE2J1	hsa-miR-302c-3p	86.624	NM_016021
UBE2J1	hsa-miR-372-3p	86.624	NM_016021
UBE2J1	hsa-miR-520c-3p	86.624	NM_016021
UBE2J1	hsa-miR-302b-3p	86.624	NM_016021
UBE2J1	hsa-miR-520b-3p	86.624	NM_016021
UBE2J1	hsa-miR-373-3p	86.624	NM_016021
UBE2J1	hsa-miR-520a-3p	86.624	NM_016021
UBE2J1	hsa-miR-520d-3p	86.624	NM_016021
UBE2J1	hsa-miR-302a-3p	86.624	NM_016021
UBE2J1	hsa-miR-520e-3p	86.624	NM_016021
UBE2J1	hsa-miR-302d-3p	86.624	NM_016021
UBE2J1	hsa-miR-1297	86.1162	NM_016021
UBE2J1	hsa-miR-26a-5p	86.1162	NM_016021
UBE2J1	hsa-miR-208b-3p	85.6454	NM_016021
UBE2J1	hsa-miR-208a-3p	85.6454	NM_016021
UBE2J1	hsa-miR-605-3p	84.5834	NM_016021
UBE2J1	hsa-miR-6505-3p	84.5613	NM_016021
UBE2J1	hsa-miR-548v	84.1957	NM_016021
UBE2J1	hsa-miR-221-3p	83.6718	NM_016021
UBE2J1	hsa-miR-222-3p	83.6718	NM_016021
UBE2J1	hsa-miR-5690	83.5934	NM_016021
UBE2J1	hsa-miR-6507-3p	83.5781	NM_016021
UBE2J1	hsa-miR-6818-5p	82.9913	NM_016021
UBE2J1	hsa-miR-103b	82.973	NM_016021
UBE2J1	hsa-miR-26b-5p	82.4695	NM_016021
UBE2J1	hsa-miR-629-3p	80.9602	NM_016021
UBE2J1	hsa-miR-3136-5p	80.6347	NM_016021
UBE2J1	hsa-miR-4439	80.6347	NM_016021

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Motifs and transcription factors (TFs) regulating UBE2J1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2J1	metacluster_7.13	ZFX (directAnnotation).
UBE2J1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
UBE2J1	metacluster_151.2	ZNF23 (directAnnotation).
UBE2J1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
UBE2J1	transfac_pro__M05479	ZNF580 (directAnnotation).
UBE2J1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBE2J1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
UBE2J1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBE2J1	metacluster_182.10	ZFX (directAnnotation).
UBE2J1	transfac_pro__M06071	ZNF814 (directAnnotation).
UBE2J1	jaspar__MA0748.2	YY2 (directAnnotation).
UBE2J1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
UBE2J1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBE2J1	jaspar__MA0079.5	SP1 (directAnnotation).
UBE2J1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
UBE2J1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
UBE2J1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
UBE2J1	transfac_pro__M06213	ZNF267 (directAnnotation).
UBE2J1	transfac_pro__M06035	ZNF749 (directAnnotation).
UBE2J1	transfac_pro__M01861	ATF1 (directAnnotation).
UBE2J1	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
UBE2J1	jaspar__MA1596.1	ZNF460 (directAnnotation).
UBE2J1	metacluster_52.11	ZNF184 (directAnnotation).
UBE2J1	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
UBE2J1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
UBE2J1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
UBE2J1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
UBE2J1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
UBE2J1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
UBE2J1	transfac_pro__M01783	SP2 (directAnnotation).
UBE2J1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UBE2J1	cisbp__M00341	PAX6 (directAnnotation).
UBE2J1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
UBE2J1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
UBE2J1	transfac_pro__M01253	CNOT3 (directAnnotation).
UBE2J1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
UBE2J1	cisbp__M00968	MTF2 (directAnnotation).
UBE2J1	transfac_pro__M04817	ZBTB33 (directAnnotation).
UBE2J1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
UBE2J1	transfac_pro__M02089	E2F3 (directAnnotation).
UBE2J1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
UBE2J1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
UBE2J1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
UBE2J1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
UBE2J1	metacluster_22.13	MAFK (inferredBy_Orthology).
UBE2J1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
UBE2J1	metacluster_22.15	BACH1 (directAnnotation).
UBE2J1	metacluster_22.14	BACH1 (inferredBy_Orthology).
UBE2J1	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
UBE2J1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."