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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2G1

Summary for UBE2G1

Gene information	Gene symbol	UBE2G1
	Ensembl ID	ENSG00000132388
	Entrez ID	7326
	Gene name	ubiquitin conjugating enzyme E2 G1
	Synonyms	UBC7\|UBE2G
	Gene type	protein_coding
	UniProtAcc	P62253

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Dataset with differentially expressed gene: UBE2G1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.254807	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.337827	1.25e-07
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.361992	4.21e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.340367	0.00e+00

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Expression of UBE2G1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2G1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2G1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2G1	hsa-miR-345-3p	98.9943	NM_003342
UBE2G1	hsa-miR-1271-5p	98.7833	NM_003342
UBE2G1	hsa-miR-12133	98.7833	NM_003342
UBE2G1	hsa-miR-96-5p	98.7833	NM_003342
UBE2G1	hsa-miR-30a-3p	98.4604	NM_003342
UBE2G1	hsa-miR-30e-3p	98.4604	NM_003342
UBE2G1	hsa-miR-30d-3p	98.4604	NM_003342
UBE2G1	hsa-miR-504-5p	97.9544	NM_003342
UBE2G1	hsa-miR-4725-5p	97.9544	NM_003342
UBE2G1	hsa-miR-5003-5p	97.7989	NM_003342
UBE2G1	hsa-miR-1297	97.3473	NM_003342
UBE2G1	hsa-let-7c-3p	97.029	NM_003342
UBE2G1	hsa-miR-4670-3p	96.2435	NM_003342
UBE2G1	hsa-miR-26a-5p	96.2424	NM_003342
UBE2G1	hsa-miR-26b-5p	96.2424	NM_003342
UBE2G1	hsa-miR-4465	95.8723	NM_003342
UBE2G1	hsa-miR-5011-5p	95.4677	NM_003342
UBE2G1	hsa-miR-6853-3p	95.2624	NM_003342
UBE2G1	hsa-miR-5002-5p	93.4834	NM_003342
UBE2G1	hsa-miR-4729	93.4814	NM_003342
UBE2G1	hsa-miR-150-3p	93.0837	NM_003342
UBE2G1	hsa-miR-3148	92.6632	NM_003342
UBE2G1	hsa-miR-6868-5p	91.5268	NM_003342
UBE2G1	hsa-miR-144-3p	91.2747	NM_003342
UBE2G1	hsa-miR-16-1-3p	90.7563	NM_003342
UBE2G1	hsa-miR-335-5p	90.5123	NM_003342
UBE2G1	hsa-miR-493-5p	90.493	NM_003342
UBE2G1	hsa-miR-17-3p	90.4845	NM_003342
UBE2G1	hsa-miR-137-3p	90.2964	NM_003342
UBE2G1	hsa-miR-4319	89.8971	NM_003342
UBE2G1	hsa-miR-4715-5p	89.8455	NM_003342
UBE2G1	hsa-miR-6844	89.8207	NM_003342
UBE2G1	hsa-miR-548t-3p	89.6544	NM_003342
UBE2G1	hsa-miR-548aa	89.6544	NM_003342
UBE2G1	hsa-miR-548ap-3p	89.6544	NM_003342
UBE2G1	hsa-miR-5584-5p	89.6198	NM_003342
UBE2G1	hsa-miR-3691-5p	89.4743	NM_003342
UBE2G1	hsa-miR-1290	88.9419	NM_003342
UBE2G1	hsa-miR-10523-5p	88.763	NM_003342
UBE2G1	hsa-miR-6720-5p	88.6947	NM_003342
UBE2G1	hsa-miR-6512-3p	88.6947	NM_003342
UBE2G1	hsa-miR-891a-3p	88.5849	NM_003342
UBE2G1	hsa-miR-1827	88.1489	NM_003342
UBE2G1	hsa-miR-125a-5p	88.0518	NM_003342
UBE2G1	hsa-miR-125b-5p	88.0518	NM_003342
UBE2G1	hsa-miR-4752	87.6978	NM_003342
UBE2G1	hsa-miR-190a-3p	87.4307	NM_003342
UBE2G1	hsa-let-7a-2-3p	87.152	NM_003342
UBE2G1	hsa-let-7g-3p	87.152	NM_003342
UBE2G1	hsa-miR-139-3p	86.3311	NM_003342

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Motifs and transcription factors (TFs) regulating UBE2G1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2G1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
UBE2G1	transfac_pro__M04950	EGR1 (directAnnotation).
UBE2G1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
UBE2G1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBE2G1	transfac_pro__M00652	NRF1 (directAnnotation).
UBE2G1	hdpi__ETV4	ETV4 (directAnnotation).
UBE2G1	transfac_pro__M04866	HDAC2 (directAnnotation).
UBE2G1	jaspar__MA1122.1	TFDP1 (directAnnotation).
UBE2G1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
UBE2G1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
UBE2G1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
UBE2G1	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
UBE2G1	transfac_pro__M06786	ZNF646 (directAnnotation).
UBE2G1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
UBE2G1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
UBE2G1	transfac_pro__M04944	GABPA (directAnnotation).
UBE2G1	transfac_pro__M06516	ZNF418 (directAnnotation).
UBE2G1	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
UBE2G1	transfac_pro__M01298	MECP2 (directAnnotation).
UBE2G1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
UBE2G1	transfac_pro__M06135	ZNF28 (directAnnotation).
UBE2G1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
UBE2G1	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
UBE2G1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
UBE2G1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
UBE2G1	transfac_pro__M06331	ZNF343 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."