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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBASH3B

Summary for UBASH3B

Gene information	Gene symbol	UBASH3B
	Ensembl ID	ENSG00000154127
	Entrez ID	84959
	Gene name	ubiquitin associated and SH3 domain containing B
	Synonyms	KIAA1959\|STS-1\|TULA-2\|TULA2
	Gene type	protein_coding
	UniProtAcc	Q8TF42

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Dataset with differentially expressed gene: UBASH3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.2794	1.19e-04
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.601367	1.05e-40
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.36747	5.79e-19
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.405846	0.00e+00

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Expression of UBASH3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBASH3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBASH3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBASH3B	hsa-miR-519d-5p	96.9595	NM_032873
UBASH3B	hsa-miR-1270	96.3238	NM_032873
UBASH3B	hsa-miR-620	96.3238	NM_032873
UBASH3B	hsa-miR-4729	96.1783	NM_032873
UBASH3B	hsa-miR-595	94.8463	NM_032873
UBASH3B	hsa-miR-4758-5p	94.8152	NM_032873
UBASH3B	hsa-miR-1238-5p	94.8152	NM_032873
UBASH3B	hsa-miR-190b-3p	92.8354	NM_032873
UBASH3B	hsa-miR-4303	92.6794	NM_032873
UBASH3B	hsa-miR-5100	91.9496	NM_032873
UBASH3B	hsa-miR-6766-3p	91.1738	NM_032873
UBASH3B	hsa-miR-4782-3p	91.1738	NM_032873
UBASH3B	hsa-miR-219a-5p	91.1738	NM_032873
UBASH3B	hsa-miR-92b-3p	90.8521	NM_032873
UBASH3B	hsa-miR-32-5p	90.8521	NM_032873
UBASH3B	hsa-miR-92a-3p	90.8521	NM_032873
UBASH3B	hsa-miR-450b-5p	90.7448	NM_032873
UBASH3B	hsa-miR-3671	90.7212	NM_032873
UBASH3B	hsa-miR-9983-3p	90.4137	NM_032873
UBASH3B	hsa-miR-182-5p	90.0426	NM_032873
UBASH3B	hsa-miR-4511	89.3568	NM_032873
UBASH3B	hsa-miR-129-5p	88.9559	NM_032873
UBASH3B	hsa-miR-586	88.7029	NM_032873
UBASH3B	hsa-miR-25-3p	88.2657	NM_032873
UBASH3B	hsa-miR-363-3p	88.2657	NM_032873
UBASH3B	hsa-miR-367-3p	88.2657	NM_032873
UBASH3B	hsa-miR-548l	88.1597	NM_032873
UBASH3B	hsa-miR-5187-3p	87.8488	NM_032873
UBASH3B	hsa-miR-520d-5p	86.1125	NM_032873
UBASH3B	hsa-miR-524-5p	86.1125	NM_032873
UBASH3B	hsa-miR-9-5p	85.8865	NM_032873
UBASH3B	hsa-miR-6772-3p	85.8695	NM_032873
UBASH3B	hsa-miR-515-5p	85.7139	NM_032873
UBASH3B	hsa-miR-519e-5p	85.7139	NM_032873
UBASH3B	hsa-miR-3609	85.6584	NM_032873
UBASH3B	hsa-miR-548ah-5p	85.6584	NM_032873
UBASH3B	hsa-miR-6753-5p	85.1474	NM_032873
UBASH3B	hsa-miR-452-3p	85.1302	NM_032873
UBASH3B	hsa-miR-4732-3p	83.9094	NM_032873
UBASH3B	hsa-miR-510-3p	83.6709	NM_032873
UBASH3B	hsa-miR-4742-3p	83.6183	NM_032873
UBASH3B	hsa-miR-323a-3p	83.4643	NM_032873
UBASH3B	hsa-miR-3157-5p	83.392	NM_032873
UBASH3B	hsa-miR-1252-3p	82.9491	NM_032873
UBASH3B	hsa-miR-4308	82.9341	NM_032873
UBASH3B	hsa-miR-3192-5p	82.8757	NM_032873
UBASH3B	hsa-miR-486-5p	82.6519	NM_032873
UBASH3B	hsa-miR-3059-5p	82.4411	NM_032873
UBASH3B	hsa-miR-3646	82.2795	NM_032873
UBASH3B	hsa-miR-6780a-3p	81.9913	NM_032873

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Motifs and transcription factors (TFs) regulating UBASH3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBASH3B	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
UBASH3B	jaspar__MA1483.2	ELF2 (directAnnotation).
UBASH3B	transfac_pro__M05628	ZNF735 (directAnnotation).
UBASH3B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
UBASH3B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
UBASH3B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
UBASH3B	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
UBASH3B	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
UBASH3B	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
UBASH3B	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
UBASH3B	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
UBASH3B	transfac_pro__M04748	GABPA (directAnnotation).
UBASH3B	swissregulon__hs__ELF2	ELF2 (directAnnotation).
UBASH3B	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
UBASH3B	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
UBASH3B	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
UBASH3B	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
UBASH3B	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
UBASH3B	transfac_pro__M04944	GABPA (directAnnotation).
UBASH3B	hdpi__FLI1	FLI1 (directAnnotation).
UBASH3B	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
UBASH3B	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
UBASH3B	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
UBASH3B	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
UBASH3B	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
UBASH3B	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
UBASH3B	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
UBASH3B	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."