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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBAP1

Summary for UBAP1

Gene information	Gene symbol	UBAP1
	Ensembl ID	ENSG00000165006
	Entrez ID	51271
	Gene name	ubiquitin associated protein 1
	Synonyms	UBAP
	Gene type	protein_coding
	UniProtAcc	Q9NZ09

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Dataset with differentially expressed gene: UBAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.455486	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.448474	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.681297	0.00e+00

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Expression of UBAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBAP1	hsa-miR-4760-5p	99.8049	NM_001171204
UBAP1	hsa-miR-8061	99.6313	NM_001171204
UBAP1	hsa-miR-7161-3p	94.9203	NM_001171204
UBAP1	hsa-miR-10522-5p	93.9521	NM_001171201
UBAP1	hsa-miR-376a-5p	93.8013	NM_001171204
UBAP1	hsa-miR-548p	91.4372	NM_001171201
UBAP1	hsa-miR-199b-5p	91.1112	NM_001171201
UBAP1	hsa-miR-296-5p	90.3349	NM_001171204
UBAP1	hsa-miR-6868-5p	89.6793	NM_001171201
UBAP1	hsa-miR-7159-3p	89.6253	NM_001171204
UBAP1	hsa-miR-4694-5p	89.3467	NM_001171201
UBAP1	hsa-miR-5196-5p	88.4202	NM_001171204
UBAP1	hsa-miR-4747-5p	88.4202	NM_001171204
UBAP1	hsa-miR-548as-3p	88.3185	NM_001171201
UBAP1	hsa-miR-501-5p	88.1852	NM_001171204
UBAP1	hsa-miR-3121-5p	88.0557	NM_001171204
UBAP1	hsa-miR-199a-5p	87.9467	NM_001171201
UBAP1	hsa-miR-374c-5p	87.4858	NM_001171201
UBAP1	hsa-miR-655-3p	87.4858	NM_001171201
UBAP1	hsa-miR-6817-3p	85.6405	NM_001171204
UBAP1	hsa-miR-3918	85.0211	NM_001171201
UBAP1	hsa-miR-369-3p	81.1831	NM_001171201
UBAP1	hsa-miR-3185	81.1521	NM_001171201
UBAP1	hsa-miR-873-3p	80.495	NM_001171204
UBAP1	hsa-miR-4766-3p	80.4523	NM_001171201

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Motifs and transcription factors (TFs) regulating UBAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBAP1	metacluster_135.11	NR2C2 (directAnnotation).
UBAP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBAP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBAP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBAP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
UBAP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBAP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBAP1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBAP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBAP1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
UBAP1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
UBAP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
UBAP1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
UBAP1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
UBAP1	transfac_pro__M01973	PLAG1 (directAnnotation).
UBAP1	transfac_pro__M01303	SP1 (directAnnotation).
UBAP1	metacluster_143.13	ZBTB7A (directAnnotation).
UBAP1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
UBAP1	transfac_pro__M02898	SMAD3 (directAnnotation).
UBAP1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
UBAP1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
UBAP1	jaspar__MA1522.1	MAZ (directAnnotation).
UBAP1	transfac_pro__M06362	ZNF730 (directAnnotation).
UBAP1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
UBAP1	taipale_tf_pairs__TEAD4_CEBPD_RGWATGYNNTTRCGYAAN_CAP	CEBPD; TEAD4 (directAnnotation).
UBAP1	transfac_pro__M05845	ZSCAN29 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."