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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBA6

Summary for UBA6

Gene information	Gene symbol	UBA6
	Ensembl ID	ENSG00000033178
	Entrez ID	55236
	Gene name	ubiquitin like modifier activating enzyme 6
	Synonyms	FLJ10808\|UBE1L2
	Gene type	protein_coding
	UniProtAcc	A0AVT1

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Dataset with differentially expressed gene: UBA6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.361487	6.46e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.282086	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.269513	2.50e-37

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Expression of UBA6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBA6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBA6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBA6	hsa-miR-3163	99.2491	NM_018227
UBA6	hsa-miR-374c-5p	97.8086	NM_018227
UBA6	hsa-miR-655-3p	97.8086	NM_018227
UBA6	hsa-miR-6716-5p	96.5972	NM_018227
UBA6	hsa-miR-449b-3p	95.9207	NM_018227
UBA6	hsa-miR-95-5p	95.815	NM_018227
UBA6	hsa-miR-3646	95.6886	NM_018227
UBA6	hsa-miR-5006-3p	95.5838	NM_018227
UBA6	hsa-miR-4755-5p	95.5838	NM_018227
UBA6	hsa-miR-4254	95.1193	NM_018227
UBA6	hsa-miR-190a-3p	95.0522	NM_018227
UBA6	hsa-miR-145-5p	94.711	NM_018227
UBA6	hsa-miR-5195-3p	94.711	NM_018227
UBA6	hsa-miR-3941	94.5814	NM_018227
UBA6	hsa-miR-664a-3p	93.4445	NM_018227
UBA6	hsa-miR-369-3p	93.2881	NM_018227
UBA6	hsa-miR-1302	91.1801	NM_018227
UBA6	hsa-miR-1248	90.8061	NM_018227
UBA6	hsa-miR-4698	89.9296	NM_018227
UBA6	hsa-miR-5692a	89.6067	NM_018227
UBA6	hsa-miR-892c-3p	89.3941	NM_018227
UBA6	hsa-miR-4676-3p	89.3941	NM_018227
UBA6	hsa-miR-452-5p	89.3941	NM_018227
UBA6	hsa-miR-3928-3p	89.1564	NM_018227
UBA6	hsa-miR-4680-3p	88.982	NM_018227
UBA6	hsa-miR-4446-5p	88.494	NM_018227
UBA6	hsa-miR-548g-3p	88.396	NM_018227
UBA6	hsa-miR-204-5p	87.7373	NM_018227
UBA6	hsa-miR-211-5p	87.7373	NM_018227
UBA6	hsa-miR-128-3p	87.4706	NM_018227
UBA6	hsa-miR-216a-3p	87.4706	NM_018227
UBA6	hsa-miR-3681-3p	87.4706	NM_018227
UBA6	hsa-miR-4680-5p	87.4473	NM_018227
UBA6	hsa-miR-4760-3p	87.4154	NM_018227
UBA6	hsa-miR-5688	87.3041	NM_018227
UBA6	hsa-miR-1277-5p	87.1883	NM_018227
UBA6	hsa-miR-203b-3p	86.9933	NM_018227
UBA6	hsa-miR-4298	86.7577	NM_018227
UBA6	hsa-miR-623	85.5703	NM_018227
UBA6	hsa-miR-6718-5p	85.0149	NM_018227
UBA6	hsa-miR-203b-5p	85.0149	NM_018227
UBA6	hsa-miR-520d-5p	84.9776	NM_018227
UBA6	hsa-miR-524-5p	84.9776	NM_018227
UBA6	hsa-miR-559	84.7629	NM_018227
UBA6	hsa-miR-5699-5p	84.6909	NM_018227
UBA6	hsa-miR-507	83.9224	NM_018227
UBA6	hsa-miR-6868-3p	83.7233	NM_018227
UBA6	hsa-miR-4672	83.6005	NM_018227
UBA6	hsa-miR-1250-3p	83.3831	NM_018227
UBA6	hsa-miR-495-3p	82.8515	NM_018227

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Motifs and transcription factors (TFs) regulating UBA6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBA6	metacluster_151.2	ZNF23 (directAnnotation).
UBA6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
UBA6	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
UBA6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBA6	hdpi__ETV4	ETV4 (directAnnotation).
UBA6	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
UBA6	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
UBA6	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UBA6	transfac_pro__M01122	ZNF219 (directAnnotation).
UBA6	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
UBA6	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
UBA6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBA6	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
UBA6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBA6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
UBA6	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
UBA6	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
UBA6	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
UBA6	transfac_pro__M01973	PLAG1 (directAnnotation).
UBA6	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
UBA6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBA6	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
UBA6	hdpi__TP73	TP73 (directAnnotation).
UBA6	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
UBA6	transfac_pro__M04913	ZBTB7A (directAnnotation).
UBA6	transfac_pro__M06249	ZNF616 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."