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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: UACA

Summary for UACA

Gene informationGene symbol

UACA

Ensembl ID

ENSG00000137831

Entrez ID

55075

Gene nameuveal autoantigen with coiled-coil domains and ankyrin repeats
SynonymsFLJ10128|KIAA1561
Gene typeprotein_coding
UniProtAcc

Q9BZF9


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Dataset with differentially expressed gene: UACA

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-1.187410.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.6743770.00e+00

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Expression of UACA in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to UACA

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UACA

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
UACAhsa-miR-3688-3p95.4389NM_001008224
UACAhsa-miR-391092.7814NM_001008224
UACAhsa-miR-31-5p92.1216NM_001008224
UACAhsa-miR-205391.0385NM_001008224
UACAhsa-miR-302f90.5906NM_018003
UACAhsa-miR-4774-3p89.7977NM_018003
UACAhsa-miR-6837-5p88.9644NM_018003
UACAhsa-miR-4685-5p88.9644NM_018003
UACAhsa-miR-450488.6568NM_018003
UACAhsa-miR-4708-5p88.4647NM_018003
UACAhsa-miR-5583-3p87.6206NM_018003
UACAhsa-miR-337-3p86.3217NM_001008224
UACAhsa-miR-1537-3p85.6629NM_018003
UACAhsa-miR-513c-5p85.2657NM_018003
UACAhsa-miR-514b-5p85.2657NM_018003
UACAhsa-miR-6832-5p85.2573NM_018003
UACAhsa-miR-590-3p84.9636NM_018003
UACAhsa-miR-9-5p84.4069NM_018003
UACAhsa-miR-190b-3p84.2004NM_001008224
UACAhsa-miR-3124-3p84.1627NM_018003
UACAhsa-miR-5582-3p83.9233NM_001008224
UACAhsa-miR-4735-5p82.6855NM_018003
UACAhsa-miR-443582.5782NM_001008224
UACAhsa-miR-570-3p81.8342NM_018003
UACAhsa-miR-1226-3p81.2047NM_018003
UACAhsa-miR-63480.3051NM_018003
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Motifs and transcription factors (TFs) regulating UACA

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
UACAmetacluster_135.11NR2C2 (directAnnotation).
UACAmetacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UACAtfdimers__MD00038TFAP2C (directAnnotation).
UACAmetacluster_144.3ZNF704; ZNF704 (directAnnotation).
UACAmetacluster_7.13ZFX (directAnnotation).
UACAkznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
UACAcisbp__M00968MTF2 (directAnnotation).
UACAmetacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UACAmetacluster_160.20JUND; PRDM15 (directAnnotation).
UACAcisbp__M00341PAX6 (directAnnotation).
UACAmetacluster_198.3ZFP64 (directAnnotation).
UACAmetacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UACAmetacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UACAjaspar__MA0185.1DEAF1 (inferredBy_Orthology).
UACAmetacluster_61.1DEAF1; DEAF1 (directAnnotation).
UACAcisbp__M00788ZFY (inferredBy_Orthology).
UACAkznf__ZNF213_Schmitges2016_RCADEZNF213 (directAnnotation).
UACAmetacluster_175.1ZNF283 (directAnnotation).
UACAhdpi__ZNF304ZNF304 (directAnnotation).
UACAtransfac_pro__M02844BCL6B (inferredBy_Orthology).
UACAmetacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
UACAmetacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UACAtransfac_pro__M01199TRIM28 (directAnnotation).
UACAkznf__ZNF682_Isakova2017_SMiLE-seqZNF682 (directAnnotation).
UACAmetacluster_151.2ZNF23 (directAnnotation).
UACAtransfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UACAtransfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UACAtransfac_pro__M03806ZBTB7C (directAnnotation).
UACAtransfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UACAhdpi__TP73TP73 (directAnnotation).
UACAmetacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
UACAhdpi__ETV4ETV4 (directAnnotation).
UACAmetacluster_33.8BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
UACAmetacluster_141.6MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
UACAtaipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
UACAtaipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAPETV1; FOXO1 (directAnnotation).
UACAjaspar__MA0748.2YY2 (directAnnotation).
UACAtransfac_pro__M01298MECP2 (directAnnotation).
UACAmetacluster_7.5PLAGL1; PLAGL1 (directAnnotation).
UACAtaipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_reprEOMES; MYBL1 (directAnnotation).
UACAmetacluster_182.10ZFX (directAnnotation).
UACAtransfac_pro__M00492STAT1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."