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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TYMS

Summary for TYMS

Gene information	Gene symbol	TYMS
	Ensembl ID	ENSG00000176890
	Entrez ID	7298
	Gene name	thymidylate synthetase
	Synonyms	HsT422\|TMS\|TS\|Tsase
	Gene type	protein_coding
	UniProtAcc	P04818

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Dataset with differentially expressed gene: TYMS

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.546116	1.47e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.4059	1.57e-24
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.542578	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.436949	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	1.03346	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.416777	1.98e-21
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.30722	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.501091	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.877084	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.54761	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.448396	6.29e-08
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.29433	6.85e-16
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.301457	8.68e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.624894	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.668331	3.74e-43
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.347945	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.25169	4.40e-03
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.714001	0.00e+00

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Expression of TYMS in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TYMS

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TYMS	Epigenetic Alteration of DNA, RNA or Protein
TYMS	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating TYMS

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TYMS	hsa-miR-6834-5p	86.4347	NM_001071

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Motifs and transcription factors (TFs) regulating TYMS

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TYMS	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
TYMS	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
TYMS	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TYMS	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TYMS	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TYMS	cisbp__M07938	E2F1 (directAnnotation).
TYMS	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TYMS	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TYMS	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TYMS	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TYMS	transfac_pro__M02090	E2F4 (directAnnotation).
TYMS	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TYMS	jaspar__MA1122.1	TFDP1 (directAnnotation).
TYMS	transfac_pro__M02089	E2F3 (directAnnotation).
TYMS	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TYMS	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TYMS	transfac_pro__M02898	SMAD3 (directAnnotation).
TYMS	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
TYMS	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TYMS	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TYMS	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
TYMS	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TYMS	transfac_pro__M04918	EGR1 (directAnnotation).
TYMS	jaspar__MA0748.2	YY2 (directAnnotation).
TYMS	transfac_pro__M00492	STAT1 (directAnnotation).
TYMS	tfdimers__MD00549	CRX (directAnnotation).
TYMS	hdpi__TP73	TP73 (directAnnotation).
TYMS	transfac_pro__M04950	EGR1 (directAnnotation).
TYMS	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TYMS	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TYMS	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TYMS	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TYMS	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TYMS	transfac_pro__M12697	ZNF142 (directAnnotation).
TYMS	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TYMS	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TYMS	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
TYMS	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
TYMS	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
TYMS	jaspar__MA1708.1	ETV7 (directAnnotation).
TYMS	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
TYMS	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
TYMS	transfac_pro__M06258	ZNF345 (directAnnotation).
TYMS	transfac_pro__M06432	ZNF571 (directAnnotation).
TYMS	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
TYMS	taipale_tf_pairs__GCM1_SOX2_RTRSGGGNNNATTGTKY_CAP_repr	GCM1; SOX2 (directAnnotation).
TYMS	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TYMS	hdpi__NRL	NRL (directAnnotation).
TYMS	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
TYMS	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TYMS	"10-Propargyl-5,8-Dideazafolic Acid"	DB03541	small molecule
TYMS	"2,4-Diamino-5-phenyl-6-ethylpyrimidine"	DB07577	small molecule
TYMS	"6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE"	DB08734	small molecule
TYMS	"ANX-510"	DB05308	small molecule
TYMS	"Capecitabine"	DB01101	small molecule
TYMS	"Deoxyuridine monophosphate"	DB03800	small molecule
TYMS	"Floxuridine"	DB00322	small molecule
TYMS	"Fluorouracil"	DB00544	small molecule
TYMS	"Gemcitabine"	DB00441	small molecule
TYMS	"Methotrexate"	DB00563	small molecule
TYMS	"N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide"	DB08479	small molecule
TYMS	"N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide"	DB08478	small molecule
TYMS	"OSI-7904L"	DB05457	small molecule
TYMS	"Pemetrexed"	DB00642	small molecule
TYMS	"Pralatrexate"	DB06813	small molecule
TYMS	"Raltitrexed"	DB00293	small molecule
TYMS	"S,S-(2-Hydroxyethyl)Thiocysteine"	DB04530	small molecule
TYMS	"Tegafur"	DB09256	small molecule
TYMS	"Tegafur-uracil"	DB09327	small molecule
TYMS	"Thymectacin"	DB05116	small molecule
TYMS	"Thymidine monophosphate"	DB01643	small molecule
TYMS	"Trifluridine"	DB00432	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."