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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TXNRD2

Summary for TXNRD2

Gene information	Gene symbol	TXNRD2
	Ensembl ID	ENSG00000184470
	Entrez ID	10587
	Gene name	thioredoxin reductase 2
	Synonyms	SELZ\|TR\|TR3\|TRXR2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TXNRD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.356842	3.19e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.604637	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.270646	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.444485	7.73e-35
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.368648	1.14e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.453101	5.74e-28
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.326174	2.62e-09
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.353029	0.00e+00

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Expression of TXNRD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TXNRD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TXNRD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TXNRD2	hsa-miR-523-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-519c-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-519b-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-519a-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-522-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-520c-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-518f-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-526a-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-518d-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-518e-5p	92.7641	NM_001282512
TXNRD2	hsa-miR-4720-3p	91.2074	NM_001282512
TXNRD2	hsa-miR-3613-3p	90.4261	NM_001282512
TXNRD2	hsa-miR-1270	89.1763	NM_001282512
TXNRD2	hsa-miR-153-5p	88.2514	NM_001282512
TXNRD2	hsa-miR-620	87.4748	NM_001282512
TXNRD2	hsa-miR-6722-3p	86.7752	NM_006440
TXNRD2	hsa-miR-371b-5p	86.392	NM_001282512
TXNRD2	hsa-miR-373-5p	86.392	NM_001282512
TXNRD2	hsa-miR-616-5p	86.392	NM_001282512
TXNRD2	hsa-miR-490-3p	84.9347	NM_001282512
TXNRD2	hsa-miR-12131	83.126	NM_001282512

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Motifs and transcription factors (TFs) regulating TXNRD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TXNRD2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
TXNRD2	metacluster_26.4	CDC5L; CDC5L; CDC5L; ZNF580; ZNF580 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TXNRD2	"Motexafin gadolinium"	DB05428	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."