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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TXNRD1

Summary for TXNRD1

Gene information	Gene symbol	TXNRD1
	Ensembl ID	ENSG00000198431
	Entrez ID	7296
	Gene name	thioredoxin reductase 1
	Synonyms	GRIM-12\|Trxr1\|TXNR
	Gene type	protein_coding
	UniProtAcc	Q16881

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Dataset with differentially expressed gene: TXNRD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.25321	5.68e-22
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.432688	1.28e-35
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.483469	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.386716	3.46e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.89611	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.02465	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.641805	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.61243	5.63e-31
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.94326	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.00205	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.61892	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.295656	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.542084	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	1.26036	0.00e+00

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Expression of TXNRD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TXNRD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TXNRD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TXNRD1	hsa-miR-4531	99.462	NM_182743
TXNRD1	hsa-miR-548ar-3p	99.1701	NM_001093771
TXNRD1	hsa-miR-548e-3p	98.8806	NM_001093771
TXNRD1	hsa-miR-548bc	98.8806	NM_001093771
TXNRD1	hsa-miR-548az-3p	98.8806	NM_001093771
TXNRD1	hsa-miR-548f-3p	98.8806	NM_001093771
TXNRD1	hsa-miR-548a-3p	98.8806	NM_001093771
TXNRD1	hsa-miR-5582-3p	95.073	NM_001093771
TXNRD1	hsa-miR-4802-3p	93.7471	NM_182743
TXNRD1	hsa-miR-4520-2-3p	93.2198	NM_182743
TXNRD1	hsa-miR-95-5p	92.4114	NM_182743
TXNRD1	hsa-miR-4516	91.3876	NM_182743
TXNRD1	hsa-miR-6796-5p	91.1765	NM_182743
TXNRD1	hsa-miR-500a-5p	90.7064	NM_001093771
TXNRD1	hsa-miR-4447	90.4143	NM_182743
TXNRD1	hsa-miR-5692a	90.3346	NM_182743
TXNRD1	hsa-miR-23c	88.7838	NM_001093771
TXNRD1	hsa-miR-23a-3p	88.7838	NM_001093771
TXNRD1	hsa-miR-23b-3p	88.7838	NM_001093771
TXNRD1	hsa-miR-5703	88.6769	NM_182743
TXNRD1	hsa-miR-4434	88.6769	NM_182743
TXNRD1	hsa-miR-6799-3p	88.6435	NM_001093771
TXNRD1	hsa-miR-3173-5p	88.6435	NM_001093771
TXNRD1	hsa-miR-5003-5p	87.5787	NM_182743
TXNRD1	hsa-miR-421	86.6912	NM_182743
TXNRD1	hsa-miR-124-5p	86.027	NM_182743
TXNRD1	hsa-miR-3685	85.9619	NM_001093771
TXNRD1	hsa-miR-335-3p	85.9556	NM_182743
TXNRD1	hsa-miR-4755-3p	85.7111	NM_182743
TXNRD1	hsa-miR-6752-3p	85.0505	NM_001093771
TXNRD1	hsa-miR-590-3p	84.98	NM_182743
TXNRD1	hsa-miR-6134	83.6243	NM_001093771
TXNRD1	hsa-miR-4472	82.0472	NM_182743
TXNRD1	hsa-miR-4668-3p	80.8486	NM_001093771
TXNRD1	hsa-miR-7-1-3p	80.4523	NM_001093771
TXNRD1	hsa-miR-7-2-3p	80.4523	NM_001093771
TXNRD1	hsa-miR-4775	80.406	NM_182743
TXNRD1	hsa-miR-497-3p	80.293	NM_001093771

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Motifs and transcription factors (TFs) regulating TXNRD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TXNRD1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TXNRD1	jaspar__MA1483.2	ELF2 (directAnnotation).
TXNRD1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TXNRD1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TXNRD1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TXNRD1	transfac_pro__M05298	OVOL3 (directAnnotation).
TXNRD1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TXNRD1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
TXNRD1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TXNRD1	cisbp__M08198	ELF1 (directAnnotation).
TXNRD1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TXNRD1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
TXNRD1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
TXNRD1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TXNRD1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
TXNRD1	transfac_pro__M04748	GABPA (directAnnotation).
TXNRD1	cisbp__M02645	ETS1 (directAnnotation).
TXNRD1	transfac_pro__M05817	ZNF546 (directAnnotation).
TXNRD1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
TXNRD1	metacluster_198.3	ZFP64 (directAnnotation).
TXNRD1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TXNRD1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TXNRD1	cisbp__M00788	ZFY (inferredBy_Orthology).
TXNRD1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TXNRD1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TXNRD1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
TXNRD1	metacluster_22.17	NFE2 (directAnnotation).
TXNRD1	transfac_pro__M05770	ZNF77 (directAnnotation).
TXNRD1	metacluster_22.37	BACH1 (directAnnotation).
TXNRD1	metacluster_22.11	NFE2 (directAnnotation).
TXNRD1	metacluster_22.13	MAFK (inferredBy_Orthology).
TXNRD1	metacluster_22.34	BACH2 (directAnnotation).
TXNRD1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
TXNRD1	transfac_pro__M01299	MECP2 (directAnnotation).
TXNRD1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
TXNRD1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
TXNRD1	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
TXNRD1	metacluster_155.3	PLAG1 (directAnnotation). PLAG1 (inferredBy_Orthology).
TXNRD1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
TXNRD1	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TXNRD1	"Arsenic trioxide"	DB01169	small molecule
TXNRD1	"Flavin adenine dinucleotide"	DB03147	small molecule
TXNRD1	"Fotemustine"	DB04106	small molecule
TXNRD1	"Motexafin gadolinium"	DB05428	small molecule
TXNRD1	"NADPH"	DB02338	small molecule
TXNRD1	"PX-12"	DB05448	small molecule
TXNRD1	"Spermidine"	DB03566	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."