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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TXNDC5

Summary for TXNDC5

Gene information	Gene symbol	TXNDC5
	Ensembl ID	ENSG00000239264
	Entrez ID	81567
	Gene name	thioredoxin domain containing 5
	Synonyms	EndoPDI\|ERp46\|FLJ21353\|FLJ90810\|Hcc-2\|MGC3178\|PDIA15
	Gene type	protein_coding
	UniProtAcc	Q8NBS9

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Dataset with differentially expressed gene: TXNDC5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.911016	5.96e-25
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.552824	2.65e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.418241	2.69e-20
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.769139	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	0.474594	4.25e-02

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Expression of TXNDC5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TXNDC5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TXNDC5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TXNDC5	hsa-miR-1324	93.818	NM_001145549
TXNDC5	hsa-miR-2467-5p	88.6571	NM_001145549
TXNDC5	hsa-miR-5006-3p	87.9158	NM_001145549
TXNDC5	hsa-miR-4755-5p	87.9158	NM_001145549
TXNDC5	hsa-miR-5701	87.2913	NM_001145549
TXNDC5	hsa-miR-6721-5p	86.7821	NM_001145549
TXNDC5	hsa-miR-4474-5p	85.424	NM_001145549
TXNDC5	hsa-miR-1255b-2-3p	85.13	NM_001145549
TXNDC5	hsa-miR-6839-3p	84.9852	NM_001145549
TXNDC5	hsa-miR-9-5p	84.9079	NM_001145549
TXNDC5	hsa-miR-6780b-3p	84.5404	NM_001145549
TXNDC5	hsa-miR-141-5p	84.0421	NM_001145549
TXNDC5	hsa-miR-218-5p	81.4376	NM_001145549

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Motifs and transcription factors (TFs) regulating TXNDC5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TXNDC5	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
TXNDC5	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
TXNDC5	transfac_pro__M06847	SALL3 (inferredBy_Orthology).
TXNDC5	flyfactorsurvey__Max_Mnt_SANGER_5_FBgn0017578	MAX (inferredBy_Orthology).
TXNDC5	transfac_pro__M06794	ZNF107 (directAnnotation).
TXNDC5	taipale_tf_pairs__MYCL2_SCACGTGS_HT	MYCLP1 (directAnnotation).
TXNDC5	transfac_pro__M06235	ZNF267 (directAnnotation).
TXNDC5	transfac_pro__M06009	ZNF175 (directAnnotation).
TXNDC5	metacluster_16.5	ZNF248 (directAnnotation). DMRT1 (inferredBy_Orthology).
TXNDC5	metacluster_143.19	PLAGL2; ZNF740 (directAnnotation).
TXNDC5	transfac_pro__M07078	BHLHE40 (inferredBy_Orthology).
TXNDC5	transfac_pro__M06282	ZSCAN10 (inferredBy_Orthology).
TXNDC5	taipale_tf_pairs__HOXB13_TBX3_NNNRTAAATCACACNN_CAP_repr	HOXB13; TBX3 (directAnnotation).
TXNDC5	metacluster_27.9	ZSCAN31 (directAnnotation).
TXNDC5	metacluster_10.46	MAX (inferredBy_Orthology).
TXNDC5	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
TXNDC5	tfdimers__MD00599	NR1I2; RXRA; STAT1 (directAnnotation).
TXNDC5	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
TXNDC5	transfac_pro__M05543	ZSCAN12 (inferredBy_Orthology).
TXNDC5	taipale_tf_pairs__SOX6_TBX21_RGGTGTNNNNNNNNNYATTGT_CAP_repr	SOX6; TBX21 (directAnnotation).
TXNDC5	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
TXNDC5	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
TXNDC5	jaspar__MA1934.1	FIGLA (directAnnotation).
TXNDC5	jaspar__MA1944.1	ETV5 (directAnnotation).
TXNDC5	jaspar__MA1563.2	SOX18 (directAnnotation).
TXNDC5	transfac_pro__M05566	ZSCAN25 (directAnnotation).
TXNDC5	metacluster_141.2	E2F2; E2F3 (directAnnotation).
TXNDC5	taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP	HOXA2; TEAD4 (directAnnotation).
TXNDC5	transfac_pro__M06681	ZNF436 (directAnnotation).
TXNDC5	transfac_pro__M04927	FOXA1 (directAnnotation).
TXNDC5	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
TXNDC5	transfac_pro__M06015	ZNF729 (directAnnotation).
TXNDC5	transfac_pro__M06650	ZNF670 (directAnnotation).
TXNDC5	taipale_tf_pairs__ETV2_EOMES_RCCGGANNNNNNNNNNNACACCTN_CAP_repr	EOMES; ETV2 (directAnnotation).
TXNDC5	transfac_pro__M05536	ZNF777 (directAnnotation).
TXNDC5	metacluster_188.9	FOXJ3 (directAnnotation). FOXJ3 (inferredBy_Orthology).
TXNDC5	transfac_pro__M07448	ZBED1 (directAnnotation).
TXNDC5	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
TXNDC5	transfac_pro__M06585	ZNF479 (directAnnotation).
TXNDC5	kznf__ZNF182_Imbeault2017_OM_RCADE	ZNF182 (directAnnotation).
TXNDC5	metacluster_190.2	NFATC1; NFATC1; NFATC2; NFATC2 (directAnnotation).
TXNDC5	taipale_tf_pairs__HOXD12_TBX21_AGGTGTKAAGTCGTAAA_CAP_repr	HOXD12; TBX21 (directAnnotation).
TXNDC5	transfac_pro__M01150	DMRTA2 (directAnnotation).
TXNDC5	metacluster_141.4	GLIS2 (directAnnotation).
TXNDC5	metacluster_52.5	HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2 (directAnnotation).
TXNDC5	transfac_pro__M05779	ZNF674 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."