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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TXLNA

Summary for TXLNA

Gene information	Gene symbol	TXLNA
	Ensembl ID	ENSG00000084652
	Entrez ID	200081
	Gene name	taxilin alpha
	Synonyms	DKFZp451J0118
	Gene type	protein_coding
	UniProtAcc	P40222

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Dataset with differentially expressed gene: TXLNA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.474067	0.00e+00

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Expression of TXLNA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TXLNA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TXLNA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TXLNA	hsa-miR-133a-3p	94.3588	NM_175852
TXLNA	hsa-miR-133b	94.3588	NM_175852
TXLNA	hsa-miR-6829-5p	92.1693	NM_175852
TXLNA	hsa-miR-646	92.025	NM_175852
TXLNA	hsa-miR-19a-3p	91.8492	NM_175852
TXLNA	hsa-miR-19b-3p	91.8492	NM_175852
TXLNA	hsa-miR-4291	91.6371	NM_175852
TXLNA	hsa-miR-1257	91.5205	NM_175852
TXLNA	hsa-miR-7114-3p	89.7031	NM_175852
TXLNA	hsa-miR-6827-5p	89.4296	NM_175852
TXLNA	hsa-miR-6804-3p	89.4057	NM_175852
TXLNA	hsa-miR-1180-5p	89.0314	NM_175852
TXLNA	hsa-miR-4456	86.425	NM_175852
TXLNA	hsa-miR-1253	86.0739	NM_175852
TXLNA	hsa-miR-543	85.5628	NM_175852
TXLNA	hsa-miR-3194-5p	85.5129	NM_175852
TXLNA	hsa-miR-4500	84.9481	NM_175852
TXLNA	hsa-miR-6761-5p	84.5093	NM_175852
TXLNA	hsa-miR-4492	84.0787	NM_175852
TXLNA	hsa-miR-3529-3p	83.8641	NM_175852
TXLNA	hsa-miR-6721-5p	83.7445	NM_175852
TXLNA	hsa-miR-570-3p	82.9333	NM_175852
TXLNA	hsa-miR-3944-5p	82.0026	NM_175852
TXLNA	hsa-miR-6508-3p	81.2167	NM_175852
TXLNA	hsa-miR-7977	80.254	NM_175852

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Motifs and transcription factors (TFs) regulating TXLNA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TXLNA	metacluster_7.13	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."