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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TVP23B

Summary for TVP23B

Gene information	Gene symbol	TVP23B
	Ensembl ID	ENSG00000171928
	Entrez ID	51030
	Gene name	trans-golgi network vesicle protein 23 homolog B
	Synonyms	CGI-148\|FAM18B\|FAM18B1\|YDR084C
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TVP23B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.774591	5.62e-06
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.324923	1.69e-38

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Expression of TVP23B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TVP23B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TVP23B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TVP23B	hsa-miR-548x-3p	99.501	NM_001316921
TVP23B	hsa-miR-548aj-3p	99.501	NM_001316921
TVP23B	hsa-miR-548ae-3p	99.1502	NM_001316921
TVP23B	hsa-miR-548aq-3p	99.1502	NM_001316921
TVP23B	hsa-miR-548am-3p	98.8295	NM_001316921
TVP23B	hsa-miR-548ah-3p	98.8295	NM_001316921
TVP23B	hsa-miR-548j-3p	98.8295	NM_001316921
TVP23B	hsa-let-7f-1-3p	98.0927	NM_001316919
TVP23B	hsa-let-7b-3p	98.0927	NM_001316919
TVP23B	hsa-miR-98-3p	98.0927	NM_001316919
TVP23B	hsa-let-7a-3p	98.0927	NM_001316919
TVP23B	hsa-miR-142-5p	96.6371	NM_001316921
TVP23B	hsa-miR-5590-3p	96.6371	NM_001316921
TVP23B	hsa-miR-6796-3p	93.487	NM_001316919
TVP23B	hsa-miR-4480	93.4217	NM_001316921
TVP23B	hsa-miR-561-3p	93.0732	NM_001316921
TVP23B	hsa-miR-5582-3p	91.8688	NM_001316921
TVP23B	hsa-miR-4436b-5p	91.7744	NM_001316921
TVP23B	hsa-miR-4524a-3p	91.2992	NM_001316921
TVP23B	hsa-miR-451b	90.6431	NM_001316921
TVP23B	hsa-let-7f-2-3p	89.984	NM_001316919
TVP23B	hsa-miR-4789-5p	89.984	NM_001316919
TVP23B	hsa-miR-1185-1-3p	89.984	NM_001316919
TVP23B	hsa-miR-1185-2-3p	89.984	NM_001316919
TVP23B	hsa-miR-4495	89.2283	NM_001316921
TVP23B	hsa-miR-4460	88.3214	NM_001316921
TVP23B	hsa-miR-3692-5p	86.9672	NM_001316921
TVP23B	hsa-miR-3674	85.7601	NM_001316921
TVP23B	hsa-miR-3121-3p	85.5731	NM_001316921
TVP23B	hsa-miR-374c-5p	85.4588	NM_001316921
TVP23B	hsa-miR-655-3p	85.4588	NM_001316921
TVP23B	hsa-miR-7159-5p	85.4219	NM_001316921
TVP23B	hsa-miR-6512-5p	84.5578	NM_001316921
TVP23B	hsa-miR-676-5p	83.4774	NM_001316921
TVP23B	hsa-miR-590-3p	83.172	NM_001316921
TVP23B	hsa-miR-3686	83.0187	NM_001316921
TVP23B	hsa-miR-338-5p	81.1893	NM_001316919
TVP23B	hsa-miR-93-3p	80.8416	NM_001316921

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Motifs and transcription factors (TFs) regulating TVP23B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TVP23B	metacluster_151.2	ZNF23 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."