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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TUBGCP5

Summary for TUBGCP5

Gene information	Gene symbol	TUBGCP5
	Ensembl ID	ENSG00000280807
	Entrez ID	114791
	Gene name	tubulin gamma complex associated protein 5
	Synonyms	GCP5\|KIAA1899
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TUBGCP5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.363376	1.19e-22

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Expression of TUBGCP5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TUBGCP5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TUBGCP5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TUBGCP5	hsa-miR-6730-3p	93.6996	NM_052903
TUBGCP5	hsa-miR-224-3p	91.8532	NM_001102610
TUBGCP5	hsa-miR-522-3p	91.8532	NM_001102610
TUBGCP5	hsa-miR-2054	91.0426	NM_001102610
TUBGCP5	hsa-miR-5093	87.9582	NM_052903
TUBGCP5	hsa-miR-30a-3p	87.4525	NM_001102610
TUBGCP5	hsa-miR-30e-3p	87.4525	NM_001102610
TUBGCP5	hsa-miR-30d-3p	87.4525	NM_001102610
TUBGCP5	hsa-miR-939-3p	86.4371	NM_052903
TUBGCP5	hsa-miR-4437	85.0122	NM_052903
TUBGCP5	hsa-miR-6866-5p	84.6151	NM_052903
TUBGCP5	hsa-miR-8065	81.53	NM_052903
TUBGCP5	hsa-miR-888-3p	81.0164	NM_052903

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Motifs and transcription factors (TFs) regulating TUBGCP5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TUBGCP5	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TUBGCP5	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
TUBGCP5	metacluster_7.13	ZFX (directAnnotation).
TUBGCP5	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
TUBGCP5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TUBGCP5	cisbp__M00249	WT1 (directAnnotation).
TUBGCP5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."