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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TUBB2A

Summary for TUBB2A

Gene information	Gene symbol	TUBB2A
	Ensembl ID	ENSG00000137267
	Entrez ID	7280
	Gene name	tubulin beta 2A class IIa
	Synonyms	dJ40E16.7\|TUBB\|TUBB2
	Gene type	protein_coding
	UniProtAcc	Q13885

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Dataset with differentially expressed gene: TUBB2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.288431	2.51e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.322909	7.53e-37
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.380336	3.33e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.435768	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.644479	0.00e+00

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Expression of TUBB2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TUBB2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TUBB2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TUBB2A	hsa-miR-3663-3p	97.093	NM_001069
TUBB2A	hsa-miR-5004-5p	94.7579	NM_001069
TUBB2A	hsa-miR-29b-3p	92.1553	NM_001069
TUBB2A	hsa-miR-29a-3p	92.1553	NM_001069
TUBB2A	hsa-miR-29c-3p	92.1553	NM_001069
TUBB2A	hsa-miR-4709-5p	89.3459	NM_001069
TUBB2A	hsa-miR-4643	86.7425	NM_001069
TUBB2A	hsa-miR-591	85.6379	NM_001069
TUBB2A	hsa-miR-767-5p	85.0703	NM_001069

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Motifs and transcription factors (TFs) regulating TUBB2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TUBB2A	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TUBB2A	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TUBB2A	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
TUBB2A	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
TUBB2A	cisbp__M00808	MYPOP (inferredBy_Orthology).
TUBB2A	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
TUBB2A	transfac_pro__M06259	ZNF91 (directAnnotation).
TUBB2A	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
TUBB2A	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
TUBB2A	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
TUBB2A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TUBB2A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TUBB2A	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
TUBB2A	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
TUBB2A	transfac_pro__M06108	ZNF43 (directAnnotation).
TUBB2A	transfac_pro__M06408	ZSCAN30 (directAnnotation).
TUBB2A	jaspar__MA1951.1	FOS (directAnnotation).
TUBB2A	metacluster_44.9	NKX2-2 (directAnnotation).
TUBB2A	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
TUBB2A	metacluster_27.9	ZSCAN31 (directAnnotation).
TUBB2A	metacluster_143.1	ZSCAN31 (directAnnotation).
TUBB2A	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
TUBB2A	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
TUBB2A	transfac_pro__M06799	ZSCAN12 (directAnnotation).
TUBB2A	metacluster_111.5	E4F1; E4F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TUBB2A	"CYT997"	DB05147	small molecule
TUBB2A	"Phenethyl Isothiocyanate"	DB12695	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."