Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TTLL7

Summary for TTLL7

Gene information	Gene symbol	TTLL7
	Ensembl ID	ENSG00000137941
	Entrez ID	79739
	Gene name	tubulin tyrosine ligase like 7
	Synonyms	FLJ23033
	Gene type	protein_coding
	UniProtAcc	Q6ZT98

Top

Dataset with differentially expressed gene: TTLL7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.41634	8.43e-07
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.557725	9.11e-42
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.517964	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.288437	0.00e+00

Top

Expression of TTLL7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TTLL7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TTLL7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TTLL7	hsa-miR-5696	99.2365	NM_024686
TTLL7	hsa-miR-6508-5p	95.6779	NM_024686
TTLL7	hsa-miR-8067	95.4863	NM_024686
TTLL7	hsa-miR-3180-5p	95.1996	NM_024686
TTLL7	hsa-miR-1184	93.6655	NM_024686
TTLL7	hsa-miR-30b-5p	92.9661	NM_024686
TTLL7	hsa-miR-30e-5p	92.9661	NM_024686
TTLL7	hsa-miR-30d-5p	92.9661	NM_024686
TTLL7	hsa-miR-30a-5p	92.9661	NM_024686
TTLL7	hsa-miR-30c-5p	92.9661	NM_024686
TTLL7	hsa-miR-1264	92.7918	NM_024686
TTLL7	hsa-miR-5011-5p	92.5559	NM_024686
TTLL7	hsa-miR-11399	90.5296	NM_024686
TTLL7	hsa-miR-302c-5p	90.465	NM_024686
TTLL7	hsa-miR-4729	90.4003	NM_024686
TTLL7	hsa-miR-4533	89.68	NM_024686
TTLL7	hsa-miR-4476	89.67	NM_024686
TTLL7	hsa-miR-6876-5p	89.67	NM_024686
TTLL7	hsa-miR-6847-5p	89.5944	NM_024686
TTLL7	hsa-miR-377-3p	89.3707	NM_024686
TTLL7	hsa-miR-3662	88.9393	NM_024686
TTLL7	hsa-miR-200a-3p	88.8347	NM_024686
TTLL7	hsa-miR-141-3p	88.8347	NM_024686
TTLL7	hsa-miR-4678	86.6267	NM_024686
TTLL7	hsa-miR-325	86.2893	NM_024686
TTLL7	hsa-miR-448	81.4099	NM_024686
TTLL7	hsa-miR-5010-3p	80.5518	NM_024686
TTLL7	hsa-miR-7856-5p	80.2476	NM_024686
TTLL7	hsa-miR-190a-3p	80.2274	NM_024686
TTLL7	hsa-miR-550a-3p	80.046	NM_024686

Page: 1

Top

Motifs and transcription factors (TFs) regulating TTLL7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TTLL7	transfac_pro__M06156	ZNF75D (directAnnotation).
TTLL7	jaspar__MA1483.2	ELF2 (directAnnotation).
TTLL7	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TTLL7	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TTLL7	transfac_pro__M07397	ZNF148 (directAnnotation).
TTLL7	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TTLL7	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
TTLL7	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TTLL7	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TTLL7	metacluster_7.13	ZFX (directAnnotation).
TTLL7	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TTLL7	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TTLL7	transfac_pro__M01175	ZBTB7B (directAnnotation).
TTLL7	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TTLL7	tfdimers__MD00151	CHURC1 (directAnnotation).
TTLL7	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TTLL7	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TTLL7	transfac_pro__M01303	SP1 (directAnnotation).
TTLL7	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TTLL7	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TTLL7	transfac_pro__M02090	E2F4 (directAnnotation).
TTLL7	transfac_pro__M01714	KLF15 (directAnnotation).
TTLL7	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TTLL7	jaspar__MA1122.1	TFDP1 (directAnnotation).
TTLL7	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TTLL7	transfac_pro__M02089	E2F3 (directAnnotation).
TTLL7	transfac_pro__M12604	ZNF444 (directAnnotation).
TTLL7	metacluster_3.14	WT1; WT1 (directAnnotation).
TTLL7	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
TTLL7	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TTLL7	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TTLL7	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TTLL7	cisbp__M07938	E2F1 (directAnnotation).
TTLL7	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TTLL7	transfac_pro__M07436	WT1 (directAnnotation).
TTLL7	transfac_pro__M02281	SP1 (directAnnotation).
TTLL7	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TTLL7	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TTLL7	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
TTLL7	transfac_pro__M02898	SMAD3 (directAnnotation).
TTLL7	transfac_public__M00491	PATZ1 (directAnnotation).
TTLL7	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TTLL7	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
TTLL7	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TTLL7	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TTLL7	transfac_pro__M04617	ZBTB7A (directAnnotation).
TTLL7	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
TTLL7	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TTLL7	transfac_pro__M07387	ZBTB7A (directAnnotation).
TTLL7	transfac_pro__M00716	ZBTB14 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."