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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TTC39A

Summary for TTC39A

Gene information	Gene symbol	TTC39A
	Ensembl ID	ENSG00000085831
	Entrez ID	22996
	Gene name	tetratricopeptide repeat domain 39A
	Synonyms	C1orf34\|DEME-6\|KIAA0452
	Gene type	protein_coding
	UniProtAcc	Q5SRH9

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Dataset with differentially expressed gene: TTC39A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.795586	0.00e+00

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Expression of TTC39A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TTC39A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TTC39A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TTC39A	hsa-miR-128-3p	96.2264	NM_001297665
TTC39A	hsa-miR-216a-3p	96.2264	NM_001297665
TTC39A	hsa-miR-3681-3p	94.9874	NM_001297665
TTC39A	hsa-miR-4642	90.1236	NM_001297667
TTC39A	hsa-miR-4451	89.6497	NM_001297667
TTC39A	hsa-miR-203a-3p	88.9025	NM_001297665
TTC39A	hsa-miR-4328	86.8312	NM_001297667
TTC39A	hsa-miR-3682-3p	86.6182	NM_001297667
TTC39A	hsa-miR-100-5p	86.2249	NM_001297665
TTC39A	hsa-miR-99b-5p	86.2249	NM_001297665
TTC39A	hsa-miR-99a-5p	86.2249	NM_001297665
TTC39A	hsa-miR-4521	85.4778	NM_001297667
TTC39A	hsa-miR-9985	82.1196	NM_001297665
TTC39A	hsa-miR-27b-3p	82.1196	NM_001297665
TTC39A	hsa-miR-27a-3p	82.1196	NM_001297665
TTC39A	hsa-miR-8068	80.6885	NM_001297662
TTC39A	hsa-miR-6813-3p	80.5754	NM_001297667
TTC39A	hsa-miR-5585-5p	80.5449	NM_001297667
TTC39A	hsa-miR-3120-3p	80.1713	NM_001297667
TTC39A	hsa-miR-6876-3p	80.1374	NM_001297667
TTC39A	hsa-miR-626	80.1374	NM_001297667

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Motifs and transcription factors (TFs) regulating TTC39A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TTC39A	cisbp__M02645	ETS1 (directAnnotation).
TTC39A	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
TTC39A	cisbp__M08198	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."