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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TTC17

Summary for TTC17

Gene information	Gene symbol	TTC17
	Ensembl ID	ENSG00000052841
	Entrez ID	55761
	Gene name	tetratricopeptide repeat domain 17
	Synonyms	FLJ10890
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TTC17

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.285117	1.02e-40
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.291041	1.08e-22

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Expression of TTC17 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TTC17

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TTC17

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TTC17	hsa-miR-29b-2-5p	99.2218	NM_018259
TTC17	hsa-miR-455-5p	94.1616	NM_018259
TTC17	hsa-miR-4457	94.0773	NM_001307943
TTC17	hsa-miR-24-3p	93.9595	NM_018259
TTC17	hsa-miR-5011-5p	93.5101	NM_018259
TTC17	hsa-miR-4797-3p	92.6015	NM_018259
TTC17	hsa-miR-589-5p	92.3912	NM_001307943
TTC17	hsa-miR-6885-3p	91.8647	NM_018259
TTC17	hsa-miR-579-3p	91.5433	NM_001307943
TTC17	hsa-miR-664b-3p	91.5433	NM_001307943
TTC17	hsa-miR-4311	90.9666	NM_018259
TTC17	hsa-miR-3921	90.5633	NM_018259
TTC17	hsa-miR-4653-5p	90.5633	NM_018259
TTC17	hsa-miR-6838-3p	90.2528	NM_018259
TTC17	hsa-miR-16-1-3p	89.1533	NM_018259
TTC17	hsa-miR-1275	88.7397	NM_018259
TTC17	hsa-miR-6886-3p	88.6632	NM_018259
TTC17	hsa-miR-938	88.6632	NM_018259
TTC17	hsa-miR-548k	87.3622	NM_018259
TTC17	hsa-miR-8054	87.3622	NM_018259
TTC17	hsa-miR-548av-5p	87.3622	NM_018259
TTC17	hsa-miR-6756-3p	87.1023	NM_018259
TTC17	hsa-miR-6793-3p	87.016	NM_018259
TTC17	hsa-miR-6806-5p	86.2222	NM_001307943
TTC17	hsa-miR-1264	85.9571	NM_018259
TTC17	hsa-miR-12119	85.5905	NM_018259
TTC17	hsa-miR-4765	84.7434	NM_001307943
TTC17	hsa-miR-188-3p	84.062	NM_018259
TTC17	hsa-miR-3127-3p	83.6661	NM_018259
TTC17	hsa-miR-4665-5p	82.3678	NM_018259
TTC17	hsa-miR-3613-5p	82.0299	NM_018259
TTC17	hsa-miR-548an	81.6787	NM_018259
TTC17	hsa-miR-622	80.6906	NM_018259
TTC17	hsa-miR-6761-5p	80.4012	NM_018259
TTC17	hsa-miR-6828-5p	80.315	NM_018259

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Motifs and transcription factors (TFs) regulating TTC17

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TTC17	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
TTC17	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
TTC17	metacluster_135.11	NR2C2 (directAnnotation).
TTC17	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TTC17	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TTC17	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TTC17	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TTC17	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TTC17	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TTC17	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TTC17	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TTC17	metacluster_151.2	ZNF23 (directAnnotation).
TTC17	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."