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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TSPYL1

Summary for TSPYL1

Gene information	Gene symbol	TSPYL1
	Ensembl ID	ENSG00000189241
	Entrez ID	7259
	Gene name	TSPY like 1
	Synonyms	TSPYL
	Gene type	protein_coding
	UniProtAcc	Q9H0U9

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Dataset with differentially expressed gene: TSPYL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.491857	1.40e-45
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.256231	2.14e-28
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.326848	7.06e-11
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.267204	3.92e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.466246	8.57e-27
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.250458	8.46e-07

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Expression of TSPYL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TSPYL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TSPYL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TSPYL1	hsa-miR-4775	98.068	NM_003309
TSPYL1	hsa-miR-580-5p	94.6193	NM_003309
TSPYL1	hsa-miR-493-3p	94.3589	NM_003309
TSPYL1	hsa-miR-616-5p	93.8447	NM_003309
TSPYL1	hsa-miR-371b-5p	93.8447	NM_003309
TSPYL1	hsa-miR-373-5p	93.8447	NM_003309
TSPYL1	hsa-miR-3613-3p	93.0488	NM_003309
TSPYL1	hsa-miR-3679-5p	92.0896	NM_003309
TSPYL1	hsa-miR-3148	91.7378	NM_003309
TSPYL1	hsa-miR-590-3p	91.5345	NM_003309
TSPYL1	hsa-miR-6827-3p	90.8106	NM_003309
TSPYL1	hsa-miR-6086	89.4434	NM_003309
TSPYL1	hsa-miR-377-5p	89.4068	NM_003309
TSPYL1	hsa-miR-340-3p	88.753	NM_003309
TSPYL1	hsa-miR-1185-5p	88.6585	NM_003309
TSPYL1	hsa-miR-499b-3p	88.3709	NM_003309
TSPYL1	hsa-miR-499a-3p	88.3709	NM_003309
TSPYL1	hsa-miR-449b-3p	87.6461	NM_003309
TSPYL1	hsa-miR-4251	87.4828	NM_003309
TSPYL1	hsa-miR-551b-5p	86.7437	NM_003309
TSPYL1	hsa-miR-9985	86.721	NM_003309
TSPYL1	hsa-miR-4511	86.6666	NM_003309
TSPYL1	hsa-miR-4477b	86.6488	NM_003309
TSPYL1	hsa-miR-605-3p	86.0797	NM_003309
TSPYL1	hsa-miR-5683	85.066	NM_003309
TSPYL1	hsa-miR-302c-5p	84.6316	NM_003309
TSPYL1	hsa-miR-4503	84.4043	NM_003309
TSPYL1	hsa-miR-409-3p	84.1485	NM_003309
TSPYL1	hsa-miR-4279	83.7939	NM_003309
TSPYL1	hsa-miR-6783-5p	83.5292	NM_003309
TSPYL1	hsa-miR-27a-3p	83.2764	NM_003309
TSPYL1	hsa-miR-27b-3p	83.2764	NM_003309
TSPYL1	hsa-miR-5689	82.2973	NM_003309
TSPYL1	hsa-miR-7113-3p	81.2416	NM_003309
TSPYL1	hsa-miR-4530	81.1545	NM_003309
TSPYL1	hsa-miR-587	80.5927	NM_003309

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Motifs and transcription factors (TFs) regulating TSPYL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TSPYL1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
TSPYL1	transfac_pro__M04918	EGR1 (directAnnotation).
TSPYL1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TSPYL1	metacluster_168.16	FOXG1 (inferredBy_Orthology).
TSPYL1	transfac_pro__M06993	NFE2L3 (inferredBy_Orthology).
TSPYL1	taipale_cyt_meth__PITX2_YTAATCCN_FL	PITX2 (directAnnotation).
TSPYL1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
TSPYL1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
TSPYL1	transfac_pro__M04746	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."