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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TSPAN2

Summary for TSPAN2

Gene information	Gene symbol	TSPAN2
	Ensembl ID	ENSG00000134198
	Entrez ID	10100
	Gene name	tetraspanin 2
	Synonyms	FLJ12082\|TSN2\|TSPAN-2
	Gene type	protein_coding
	UniProtAcc	O60636

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Dataset with differentially expressed gene: TSPAN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.703265	0.00e+00

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Expression of TSPAN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TSPAN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TSPAN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TSPAN2	hsa-miR-5011-5p	100	NM_001308315
TSPAN2	hsa-miR-190a-3p	100	NM_001308315
TSPAN2	hsa-miR-3924	98.6487	NM_001308315
TSPAN2	hsa-miR-8485	98.5878	NM_001308315
TSPAN2	hsa-miR-6867-5p	98.2109	NM_001308315
TSPAN2	hsa-miR-299-5p	98.1771	NM_001308315
TSPAN2	hsa-miR-4282	96.1987	NM_001308315
TSPAN2	hsa-miR-205-3p	95.17	NM_001308315
TSPAN2	hsa-miR-382-5p	94.4636	NM_001308315
TSPAN2	hsa-miR-6739-3p	94.4282	NM_001308315
TSPAN2	hsa-miR-4422	94.0563	NM_001308315
TSPAN2	hsa-miR-548ar-3p	93.1307	NM_001308315
TSPAN2	hsa-miR-525-5p	93.0336	NM_001308315
TSPAN2	hsa-miR-520a-5p	93.0336	NM_001308315
TSPAN2	hsa-miR-548a-3p	92.8488	NM_001308315
TSPAN2	hsa-miR-548f-3p	92.8488	NM_001308315
TSPAN2	hsa-miR-548bc	92.8488	NM_001308315
TSPAN2	hsa-miR-4775	92.6586	NM_001308315
TSPAN2	hsa-miR-372-5p	92.6546	NM_001308315
TSPAN2	hsa-miR-3168	92.5293	NM_001308315
TSPAN2	hsa-miR-4666a-5p	92.0369	NM_001308315
TSPAN2	hsa-miR-520e-5p	91.3726	NM_001308315
TSPAN2	hsa-miR-548e-3p	91.2419	NM_001308315
TSPAN2	hsa-miR-548az-3p	91.2419	NM_001308315
TSPAN2	hsa-miR-22-5p	91.1506	NM_001308315
TSPAN2	hsa-miR-30e-5p	90.6806	NM_001308315
TSPAN2	hsa-miR-30d-5p	90.6806	NM_001308315
TSPAN2	hsa-miR-30c-5p	90.6806	NM_001308315
TSPAN2	hsa-miR-30b-5p	90.6806	NM_001308315
TSPAN2	hsa-miR-30a-5p	90.6806	NM_001308315
TSPAN2	hsa-miR-548c-3p	90.5218	NM_001308315
TSPAN2	hsa-miR-2116-5p	90.2638	NM_001308315
TSPAN2	hsa-miR-4496	90.0602	NM_001308315
TSPAN2	hsa-miR-4677-5p	89.4764	NM_001308315
TSPAN2	hsa-miR-4753-3p	89.4543	NM_001308315
TSPAN2	hsa-miR-4692	89.0537	NM_001308315
TSPAN2	hsa-miR-590-3p	89.0091	NM_001308315
TSPAN2	hsa-miR-5581-3p	88.5741	NM_001308315
TSPAN2	hsa-miR-12136	88.5727	NM_001308315
TSPAN2	hsa-miR-130b-5p	88.3911	NM_001308315
TSPAN2	hsa-miR-300	88.085	NM_001308315
TSPAN2	hsa-miR-381-3p	88.085	NM_001308315
TSPAN2	hsa-miR-5683	88.0013	NM_001308315
TSPAN2	hsa-miR-6835-3p	87.5533	NM_001308315
TSPAN2	hsa-miR-4735-5p	87.455	NM_001308315
TSPAN2	hsa-miR-135a-3p	87.2438	NM_001308315
TSPAN2	hsa-miR-4251	87.0621	NM_001308315
TSPAN2	hsa-miR-3180-5p	87.0532	NM_001308315
TSPAN2	hsa-miR-548ax	86.9717	NM_001308315
TSPAN2	hsa-miR-548ao-5p	86.9717	NM_001308315

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Motifs and transcription factors (TFs) regulating TSPAN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TSPAN2	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."