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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIQK

Summary for TRIQK

Gene information	Gene symbol	TRIQK
	Ensembl ID	ENSG00000205133
	Entrez ID	286144
	Gene name	triple QxxK/R motif containing
	Synonyms	C8orf83\|DKFZp779L1068\|LOC286144\|PRO0845
	Gene type	protein_coding
	UniProtAcc	Q629K1

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Dataset with differentially expressed gene: TRIQK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.250237	0.00e+00

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Expression of TRIQK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIQK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIQK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIQK	hsa-miR-4743-3p	98.0475	NM_001171795
TRIQK	hsa-miR-4652-3p	96.5992	NM_001171799
TRIQK	hsa-miR-3171	94.4554	NM_001171799
TRIQK	hsa-miR-5580-3p	93.5366	NM_001171795
TRIQK	hsa-miR-8070	92.7503	NM_001171799
TRIQK	hsa-miR-10399-5p	92.2512	NM_001171795
TRIQK	hsa-miR-4659a-3p	92.2041	NM_001171799
TRIQK	hsa-miR-4659b-3p	92.2041	NM_001171799
TRIQK	hsa-miR-7154-5p	92.1149	NM_001171799
TRIQK	hsa-miR-6504-3p	91.7046	NM_001171795
TRIQK	hsa-miR-6888-3p	91.1854	NM_001171795
TRIQK	hsa-miR-3686	90.0754	NM_001171799
TRIQK	hsa-miR-4501	89.52	NM_001171799
TRIQK	hsa-miR-4715-5p	88.8282	NM_001171795
TRIQK	hsa-miR-450b-5p	88.4744	NM_001171799
TRIQK	hsa-miR-4789-5p	87.7168	NM_001171799
TRIQK	hsa-miR-548n	86.4779	NM_001171795
TRIQK	hsa-miR-4281	86.2715	NM_001171795
TRIQK	hsa-miR-495-3p	85.1804	NM_001171799
TRIQK	hsa-miR-5688	84.8901	NM_001171799
TRIQK	hsa-miR-215-3p	84.7523	NM_001171795
TRIQK	hsa-miR-519a-2-5p	84.2538	NM_001171799
TRIQK	hsa-miR-520b-5p	84.2538	NM_001171799
TRIQK	hsa-miR-6867-3p	84.1249	NM_001171799
TRIQK	hsa-miR-6819-5p	83.8862	NM_001171799
TRIQK	hsa-miR-6737-5p	83.8862	NM_001171799
TRIQK	hsa-miR-33a-5p	83.7473	NM_001171799
TRIQK	hsa-miR-33b-5p	83.7473	NM_001171799
TRIQK	hsa-miR-4677-3p	83.6346	NM_001171795
TRIQK	hsa-miR-6812-5p	83.4608	NM_001171799
TRIQK	hsa-miR-4287	83.3312	NM_001171799
TRIQK	hsa-miR-4685-3p	83.3312	NM_001171799
TRIQK	hsa-miR-4762-3p	82.0998	NM_001171799
TRIQK	hsa-miR-5685	81.9216	NM_001171799
TRIQK	hsa-miR-4690-3p	81.9216	NM_001171799
TRIQK	hsa-miR-4684-5p	81.5836	NM_001171799
TRIQK	hsa-miR-133a-3p	80.8862	NM_001171795
TRIQK	hsa-miR-133b	80.8862	NM_001171795
TRIQK	hsa-miR-5589-3p	80.8316	NM_001171795
TRIQK	hsa-miR-1252-5p	80.8034	NM_001171799
TRIQK	hsa-miR-4469	80.7925	NM_001171799
TRIQK	hsa-miR-7113-3p	80.7925	NM_001171799
TRIQK	hsa-miR-8066	80.3533	NM_001171799
TRIQK	hsa-miR-3678-3p	80.2889	NM_001171799
TRIQK	hsa-miR-4789-3p	80.2145	NM_001171799
TRIQK	hsa-miR-3182	80.015	NM_001171795

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Motifs and transcription factors (TFs) regulating TRIQK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIQK	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TRIQK	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TRIQK	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
TRIQK	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TRIQK	jaspar__MA1122.1	TFDP1 (directAnnotation).
TRIQK	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."