Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIP12

Summary for TRIP12

Gene information	Gene symbol	TRIP12
	Ensembl ID	ENSG00000153827
	Entrez ID	9320
	Gene name	thyroid hormone receptor interactor 12
	Synonyms	KIAA0045\|TRIPC\|ULF
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: TRIP12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.268773	2.93e-32

Top

Expression of TRIP12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TRIP12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TRIP12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIP12	hsa-miR-4441	99.0986	NM_001284216
TRIP12	hsa-miR-502-5p	98.7688	NM_001284216
TRIP12	hsa-miR-4270	98.2778	NM_001284216
TRIP12	hsa-miR-6754-5p	97.2393	NM_001284216
TRIP12	hsa-miR-513c-3p	94.7957	NM_001284216
TRIP12	hsa-miR-513a-3p	94.7957	NM_001284216
TRIP12	hsa-miR-155-3p	94.5238	NM_001284216
TRIP12	hsa-miR-3148	94.4937	NM_001284216
TRIP12	hsa-miR-3671	94.1609	NM_001284216
TRIP12	hsa-miR-3529-3p	94.0792	NM_001284216
TRIP12	hsa-miR-548x-3p	94.0742	NM_001284216
TRIP12	hsa-miR-548aj-3p	94.0742	NM_001284216
TRIP12	hsa-miR-491-3p	93.6189	NM_001284216
TRIP12	hsa-miR-3942-3p	92.9658	NM_001284216
TRIP12	hsa-miR-548ae-3p	92.7375	NM_001284216
TRIP12	hsa-miR-548am-3p	92.7375	NM_001284216
TRIP12	hsa-miR-548ah-3p	92.7375	NM_001284216
TRIP12	hsa-miR-548j-3p	92.7375	NM_001284216
TRIP12	hsa-miR-548aq-3p	92.7375	NM_001284216
TRIP12	hsa-miR-3606-3p	91.8277	NM_001284216
TRIP12	hsa-miR-545-3p	90.9637	NM_001284216
TRIP12	hsa-miR-5582-3p	90.3827	NM_001284216
TRIP12	hsa-miR-3613-3p	90.3343	NM_001284216
TRIP12	hsa-miR-377-3p	90.3152	NM_001284216
TRIP12	hsa-miR-3120-3p	90.288	NM_001284216
TRIP12	hsa-miR-6841-3p	89.6152	NM_001284216
TRIP12	hsa-miR-6832-3p	89.268	NM_001284216
TRIP12	hsa-miR-6762-5p	88.4994	NM_001284216
TRIP12	hsa-miR-6845-5p	88.4994	NM_001284216
TRIP12	hsa-miR-1227-5p	88.3766	NM_001284216
TRIP12	hsa-miR-4306	88.2624	NM_001284216
TRIP12	hsa-miR-558	87.69	NM_001284216
TRIP12	hsa-miR-548av-3p	87.5955	NM_001284216
TRIP12	hsa-miR-5003-5p	87.4607	NM_001284216
TRIP12	hsa-miR-10397-5p	86.4708	NM_001284216
TRIP12	hsa-miR-592	85.758	NM_001284216
TRIP12	hsa-miR-7844-5p	85.3923	NM_001284216
TRIP12	hsa-miR-3685	85.1519	NM_001284216
TRIP12	hsa-miR-1284	85.0035	NM_001284216
TRIP12	hsa-miR-6074	84.8509	NM_001284216
TRIP12	hsa-miR-3646	83.7518	NM_001284216
TRIP12	hsa-miR-1265	83.0191	NM_001284216
TRIP12	hsa-miR-1208	82.1511	NM_001284216
TRIP12	hsa-miR-4668-5p	82.0459	NM_001284216
TRIP12	hsa-miR-511-5p	81.6467	NM_001284216
TRIP12	hsa-miR-6837-3p	80.805	NM_001284216

Page: 1

Top

Motifs and transcription factors (TFs) regulating TRIP12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIP12	metacluster_7.13	ZFX (directAnnotation).
TRIP12	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TRIP12	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TRIP12	jaspar__MA1483.2	ELF2 (directAnnotation).
TRIP12	metacluster_151.2	ZNF23 (directAnnotation).
TRIP12	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TRIP12	transfac_pro__M05479	ZNF580 (directAnnotation).
TRIP12	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TRIP12	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TRIP12	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TRIP12	hdpi__ETV4	ETV4 (directAnnotation).
TRIP12	transfac_pro__M06071	ZNF814 (directAnnotation).
TRIP12	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TRIP12	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TRIP12	jaspar__MA1933.1	SREBF2 (directAnnotation).
TRIP12	jaspar__MA0079.5	SP1 (directAnnotation).
TRIP12	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
TRIP12	transfac_pro__M04826	EP300 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."