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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIM6

Summary for TRIM6

Gene information	Gene symbol	TRIM6
	Ensembl ID	ENSG00000121236
	Entrez ID	117854
	Gene name	tripartite motif containing 6
	Synonyms	RNF89
	Gene type	protein_coding
	UniProtAcc	Q9C030

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Dataset with differentially expressed gene: TRIM6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.27815	1.61e-19

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Expression of TRIM6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIM6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIM6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIM6	hsa-miR-3529-3p	97.6302	NM_001198645
TRIM6	hsa-miR-4774-5p	93.7818	NM_001198645
TRIM6	hsa-miR-921	92.0935	NM_001198645
TRIM6	hsa-miR-6073	91.3946	NM_001198645
TRIM6	hsa-miR-1539	89.4265	NM_001198645
TRIM6	hsa-miR-6761-5p	87.8887	NM_001198645
TRIM6	hsa-miR-3065-5p	87.8332	NM_001198645
TRIM6	hsa-miR-1-5p	86.8778	NM_001198645
TRIM6	hsa-miR-98-3p	85.0647	NM_001198645
TRIM6	hsa-let-7f-1-3p	85.0647	NM_001198645
TRIM6	hsa-let-7b-3p	85.0647	NM_001198645
TRIM6	hsa-let-7a-3p	85.0647	NM_001198645
TRIM6	hsa-miR-4528	84.9926	NM_001198645
TRIM6	hsa-miR-6124	84.5906	NM_001198645
TRIM6	hsa-miR-6831-5p	83.4678	NM_001198645
TRIM6	hsa-miR-3662	83.2125	NM_001198645
TRIM6	hsa-miR-196a-1-3p	82.0239	NM_001198645
TRIM6	hsa-miR-3927-3p	80.967	NM_001198645
TRIM6	hsa-miR-5009-3p	80.6598	NM_001198645
TRIM6	hsa-miR-6809-3p	80.517	NM_001003818

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Motifs and transcription factors (TFs) regulating TRIM6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIM6	metacluster_7.13	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."