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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIM58

Summary for TRIM58

Gene information	Gene symbol	TRIM58
	Ensembl ID	ENSG00000162722
	Entrez ID	25893
	Gene name	tripartite motif containing 58
	Synonyms	BIA2
	Gene type	protein_coding
	UniProtAcc	Q8NG06

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Dataset with differentially expressed gene: TRIM58

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.412004	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.382888	0.00e+00

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Expression of TRIM58 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIM58

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIM58

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIM58	hsa-miR-6770-5p	94.5967	NM_015431
TRIM58	hsa-miR-4306	94.074	NM_015431
TRIM58	hsa-miR-548n	93.1055	NM_015431
TRIM58	hsa-miR-4644	91.6473	NM_015431
TRIM58	hsa-miR-185-5p	91.6473	NM_015431
TRIM58	hsa-miR-7110-5p	88.4371	NM_015431
TRIM58	hsa-miR-8085	85.3413	NM_015431
TRIM58	hsa-miR-6731-5p	85.3413	NM_015431
TRIM58	hsa-miR-6842-5p	84.9057	NM_015431
TRIM58	hsa-miR-5681a	83.8055	NM_015431
TRIM58	hsa-miR-4474-5p	83.6909	NM_015431
TRIM58	hsa-miR-1253	83.5904	NM_015431
TRIM58	hsa-miR-4517	83.4135	NM_015431
TRIM58	hsa-miR-7159-5p	82.8958	NM_015431
TRIM58	hsa-miR-6752-5p	82.585	NM_015431
TRIM58	hsa-miR-488-3p	82.3185	NM_015431
TRIM58	hsa-miR-6808-3p	82.0005	NM_015431
TRIM58	hsa-miR-8076	81.8642	NM_015431
TRIM58	hsa-miR-585-5p	80.9885	NM_015431
TRIM58	hsa-miR-4646-3p	80.3906	NM_015431

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Motifs and transcription factors (TFs) regulating TRIM58

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIM58	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TRIM58	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
TRIM58	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TRIM58	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
TRIM58	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TRIM58	cisbp__M07938	E2F1 (directAnnotation).
TRIM58	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
TRIM58	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
TRIM58	transfac_pro__M06592	ZNF486 (directAnnotation).
TRIM58	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
TRIM58	metacluster_143.13	ZBTB7A (directAnnotation).
TRIM58	transfac_pro__M05845	ZSCAN29 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."