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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIM44

Summary for TRIM44

Gene information	Gene symbol	TRIM44
	Ensembl ID	ENSG00000166326
	Entrez ID	54765
	Gene name	tripartite motif containing 44
	Synonyms	DIPB\|MC7
	Gene type	protein_coding
	UniProtAcc	Q96DX7

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Dataset with differentially expressed gene: TRIM44

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.30319	2.49e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.278197	1.30e-32
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.357534	8.62e-34

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Expression of TRIM44 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIM44

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIM44

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIM44	hsa-miR-623	99.7637	NM_017583
TRIM44	hsa-miR-6780b-3p	99.1322	NM_017583
TRIM44	hsa-miR-4780	98.5718	NM_017583
TRIM44	hsa-miR-8485	98.3195	NM_017583
TRIM44	hsa-miR-211-5p	93.8815	NM_017583
TRIM44	hsa-miR-204-5p	93.8815	NM_017583
TRIM44	hsa-miR-4755-5p	92.776	NM_017583
TRIM44	hsa-miR-5006-3p	92.776	NM_017583
TRIM44	hsa-miR-4452	92.684	NM_017583
TRIM44	hsa-miR-144-3p	90.8503	NM_017583
TRIM44	hsa-miR-1200	88.1822	NM_017583
TRIM44	hsa-miR-4680-3p	87.521	NM_017583
TRIM44	hsa-miR-548an	87.4263	NM_017583
TRIM44	hsa-miR-302f	84.5543	NM_017583
TRIM44	hsa-miR-3692-3p	84.0021	NM_017583
TRIM44	hsa-miR-3124-3p	83.5408	NM_017583
TRIM44	hsa-miR-1248	82.855	NM_017583
TRIM44	hsa-miR-3201	82.5678	NM_017583
TRIM44	hsa-miR-324-3p	82.4867	NM_017583
TRIM44	hsa-miR-3679-3p	82.2791	NM_017583
TRIM44	hsa-miR-182-3p	82.1603	NM_017583
TRIM44	hsa-miR-4791	82.1005	NM_017583
TRIM44	hsa-miR-1910-3p	82.0499	NM_017583
TRIM44	hsa-miR-5692a	81.7125	NM_017583
TRIM44	hsa-miR-5004-5p	81.6394	NM_017583
TRIM44	hsa-miR-607	81.3791	NM_017583
TRIM44	hsa-miR-3977	81.0618	NM_017583
TRIM44	hsa-miR-1287-5p	80.8688	NM_017583

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Motifs and transcription factors (TFs) regulating TRIM44

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIM44	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
TRIM44	metacluster_52.11	ZNF184 (directAnnotation).
TRIM44	metacluster_135.11	NR2C2 (directAnnotation).
TRIM44	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TRIM44	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TRIM44	metacluster_7.13	ZFX (directAnnotation).
TRIM44	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TRIM44	cisbp__M00968	MTF2 (directAnnotation).
TRIM44	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TRIM44	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TRIM44	metacluster_198.3	ZFP64 (directAnnotation).
TRIM44	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TRIM44	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TRIM44	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TRIM44	cisbp__M00788	ZFY (inferredBy_Orthology).
TRIM44	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TRIM44	metacluster_175.1	ZNF283 (directAnnotation).
TRIM44	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TRIM44	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TRIM44	transfac_pro__M01199	TRIM28 (directAnnotation).
TRIM44	metacluster_151.2	ZNF23 (directAnnotation).
TRIM44	transfac_pro__M03806	ZBTB7C (directAnnotation).
TRIM44	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TRIM44	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TRIM44	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TRIM44	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TRIM44	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."